Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture

Journal of Biomedical Optics
Anouk L PostTon G van Leeuwen

Abstract

To detect small-scale changes in tissue with optical techniques, small sampling volumes and, therefore, short source–detector separations are required. In this case, reflectance measurements are not adequately described by the diffusion approximation. Previous studies related subdiffusive reflectance to ? or ? , which parameterize the phase function. Recently, it was demonstrated that ? predicts subdiffusive reflectance better than ? , and that ? becomes less predictive for lower numerical apertures (NAs). We derive and evaluate the parameter R p NA , which incorporates the NA of the detector and the integral of the phase function over the NA in the backward and forward directions. Monte Carlo simulations are performed for overlapping source/detector geometries for a range of phase functions, reduced scattering coefficients, NAs, and source/detector diameters. R p NA improves prediction of the measured reflectance compared to ? and ? . It is, therefore, expected that R p NA will improve derivation of optical properties from subdiffusive measurements.

References

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Jan 11, 2001·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·R K Wang, M Wilson
Dec 14, 2011·Nature Communications·Edward VitkinLev T Perelman
Nov 2, 2014·Biomedical Optics Express·Stephen Chad KanickBrian W Pogue
Mar 13, 2016·Journal of Biomedical Optics·Nico BodenschatzAlwin Kienle

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Citations

Nov 1, 2017·Journal of Biomedical Optics·Xu U ZhangHenricus J C M Sterenborg
Mar 26, 2019·Journal of Biophotonics·Xu U ZhangHenricus J C M Sterenborg
Sep 2, 2019·The Review of Scientific Instruments·S NothelferA Kienle
Feb 7, 2018·Optics Express·Fabrizio Martelli, Tiziano Binzoni
Jan 11, 2020·Journal of Biomedical Optics·Anouk L PostDirk J Faber
Apr 3, 2020·Optics Letters·Dirk J FaberTon G Van Leeuwen
Dec 8, 2020·Biomedical Optics Express·Anouk L PostTon G van Leeuwen

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