Modeling the acute neurotoxicity of styrene

Journal of Occupational and Environmental Medicine
C H PierceY So

Abstract

Styrene is a widely used industrial solvent associated with acute neurotoxicity. To investigate the relationships between exposure, blood concentrations, and the appearance of neurotoxic effects, four healthy males were exposed to styrene concentrations of 5-200 ppm in four different exposure-time profiles. A digit recognition test and P300 event-related evoked potential were used to measure neurologic function. A physiologically based kinetic (PBK) model generated close predictions of measured styrene blood concentrations, in the range of 0.01-12 mg/L, from this and 21 previous studies. Simulated peak brain concentration, durationXaverage exposure, and peak exposure level were predictive of toxicity. Central nervous system effects were expected at a blood concentration near 2.4 mg/L. A standard of 20 ppm was expected to protect styrene-exposed workers from acute central nervous system toxicity under light work conditions.

References

Mar 1, 1978·Scandinavian Journal of Work, Environment & Health·H HärkönenS Hernberg
Nov 1, 1978·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·A M Thiess, I Fleig
Dec 1, 1978·Scandinavian Journal of Work, Environment & Health·J EngströmP Ovrum
Dec 1, 1978·Scandinavian Journal of Work, Environment & Health·J EngströmE Wigaeus
Sep 1, 1976·Scandinavian Journal of Work, Environment & Health·A M Seppäläinen, H Härkönen
Aug 1, 1992·Environmental Research·C H Pierce, T N Tozer
Aug 1, 1992·British Journal of Industrial Medicine·H CheckowayR L Dills
Jan 1, 1991·American Journal of Industrial Medicine·K MurataK Yokoyama
Jul 1, 1991·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·F GobbaA Cavalleri
Nov 1, 1989·British Journal of Industrial Medicine·G TriebigH Valentin
Nov 1, 1989·British Journal of Industrial Medicine·U FlodinL Andersson
Jan 1, 1985·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·A MuttiI Franchini
Apr 1, 1986·Perceptual and Motor Skills·R M RuffR H Light
Apr 1, 1987·American Industrial Hygiene Association Journal·M E AndersenD J Paustenbach
Oct 1, 1985·Scandinavian Journal of Work, Environment & Health·G PezzagnoE Capodaglio
May 1, 1968·Archives of Environmental Health·R D StewartA W Schaffer
Dec 1, 1983·Scandinavian Journal of Work, Environment & Health·E WigaeusM B Nordqvist
Mar 30, 1984·Toxicology and Applied Pharmacology·J C Ramsey, M E Andersen
Nov 1, 1982·Acta Oto-laryngologica·L M OdkvistS R Liedgren
Jan 1, 1981·American Journal of Industrial Medicine·H NorppaM Sorsa
Aug 1, 1995·Occupational and Environmental Medicine·T EguchiH Miyake
Oct 1, 1995·Scandinavian Journal of Work, Environment & Health·D CampagnaD Drolet
Apr 1, 1996·Scandinavian Journal of Work, Environment & Health·C H PierceD A Kalman
Oct 1, 1987·Environmental Science & Technology·D B Menzel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.