Modeling the bifurcating flow in an asymmetric human lung airway

Journal of Biomechanics
Y LiuC H Zhang

Abstract

In a former paper, the inspiratory flow characteristics in a three-generation symmetric bifurcation airway have been numerically investigated using a control volume method to solve the fully three-dimensional laminar Navier-Stokes equations. The present paper extends the work to deal with asymmetric airway extracted from the 5th-11th branches of the model of Weibel (Morphometry of the Human Lung. New York Academic Press, Verlag, 1963) in order to more appropriately model human air passage. Computations are carried out in the Reynolds number range 200-1600, corresponding to mouth-air breathing rates ranging from 0.27 to 2.16l/s, representative for an averaged height man breathing from quiet to vigorous state. Particular attentions are paid to establishing relations between the Reynolds number and the overall flow characteristics, including flow patterns and pressure drop. The study shows that the ratios of airflow rate through the medial branches to that of their mother branches are the same, and this is also true for the ratios of airflow rate through the lateral branches. This partially explains why regular human breathing is not affected by airways of different sizes.

References

Jun 1, 1985·Physics in Medicine and Biology·L Koblinger, W Hofmann
Oct 1, 1969·Respiration Physiology·R C Schroter, M F Sudlow
Nov 1, 1994·Journal of Biomechanical Engineering·Y Zhao, B B Lieber
Feb 1, 1997·Journal of Biomechanical Engineering·Y ZhaoB B Lieber
Apr 6, 2002·Journal of Biomechanics·Y LiuC H Zhang

❮ Previous
Next ❯

Citations

Dec 17, 2008·Annals of Biomedical Engineering·Baoshun Ma, Kenneth R Lutchen
Jan 10, 2012·Computer Methods in Biomechanics and Biomedical Engineering·M MalvèM Doblaré
Feb 2, 2011·Journal of Biomechanical Engineering·M MalvèM Doblaré
Aug 10, 2011·Journal of Biomechanical Engineering·M MalvèM Doblaré
Dec 6, 2012·Experimental Hematology & Oncology·Chien-Yi HoTzu-Ching Shih
May 21, 2010·Journal of Biomechanics·Youbing YinChing-Long Lin
Aug 1, 2008·Journal of Biomechanics·H Y Luo, Y Liu
Aug 5, 2008·Respiratory Physiology & Neurobiology·Clement KleinstreuerZheng Li
May 15, 2007·Journal of Biomechanics·H Y LuoX L Yang
Jan 4, 2006·Computers in Biology and Medicine·X L YangJ M Yang
Mar 11, 2015·Medical Engineering & Physics·Anat RatnovskySara Naftali
Jul 25, 2014·Computers in Biology and Medicine·Bora SulVineet Rakesh
Nov 23, 2005·Journal of Biomechanics·X L YangH Y Luo
Jun 6, 2009·Journal of Biomechanics·H Y Luo, Y Liu
Nov 14, 2017·Journal of Biomechanical Engineering·Peshala P T GamageHansen A Mansy
Mar 11, 2006·Environmental Geochemistry and Health·Wenzhi CaoWeiping Wang
Feb 14, 2019·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Toshihiro SeraMasao Tanaka
Jan 9, 2020·International Journal for Numerical Methods in Biomedical Engineering·Fei JiangXian Chen
Nov 5, 2014·Journal of Biomechanical Engineering·S Negin MortazaviFatemeh Hassanipour
Jan 16, 2020·International Journal of Environmental Research and Public Health·Mohammad S IslamSuvash C Saha
Aug 14, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brijeshkumar PatelFakhrul Ahsan
Jul 25, 2017·Biomechanics and Modeling in Mechanobiology·Morteza YousefiJiyuan Tu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.