Modeling the causal relationships between symptoms associated with restless legs syndrome and the patient-reported impact of RLS

Sleep Medicine
Clete A KushidaMark J Atkinson

Abstract

The objective of this study is to examine the causal relationships between the symptoms of restless legs syndrome (RLS) and specific clinical and subjective health-related, quality of life consequences. Structural equation modeling was applied to data from a questionnaire-based observational study. The RLS morbidities of decreased functional alertness and emotional distress in our sample of patients appear to be mostly secondary to the sleep disturbance associated with RLS. There was no clear indication of any other feature of RLS affecting these two aspects of RLS morbidity. A primary treatment goal should be the reduction of the sleep disturbance of RLS, both to decrease the RLS-related nocturnal distress and to improve daytime functioning.

Associated Clinical Trials

Apr 23, 2010·John W. Winkelman, MD, PhD

References

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Citations

Dec 1, 2006·Neuropsychiatric Disease and Treatment·Clete A Kushida
Dec 1, 2006·Neuropsychiatric Disease and Treatment·Philip M Becker
Jun 10, 2011·Neuropsychiatric Disease and Treatment·Ulrike H Mitchell
Feb 3, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Clete KushidaJohn E Ware
Oct 1, 2007·Expert Review of Pharmacoeconomics & Outcomes Research·Jens P ReeseRichard C Dodel
Mar 1, 2006·Expert Opinion on Pharmacotherapy·Clete A Kushida
May 20, 2008·Expert Opinion on Drug Metabolism & Toxicology·Shilpa Chitnis
Mar 4, 2008·Expert Opinion on Pharmacotherapy·Richard K Bogan
Jan 13, 2016·Physiotherapy Theory and Practice·J Stephen GuffeyNeal Tice
Jun 1, 2010·Mayo Clinic Proceedings·Richard K BoganUNKNOWN XP060 Study Group
Jul 21, 2009·Journal of Psychosomatic Research·Andras SzentkiralyiMarta Novak
Jan 3, 2007·The American Journal of Medicine·Clete A Kushida
Sep 22, 2011·Health and Quality of Life Outcomes·Hanna ScholzMagdolna Hornyak
Oct 28, 2010·Physiotherapy Theory and Practice·Ulrike H MitchellSterling C Hilton
Oct 19, 2010·Physiotherapy Theory and Practice·Ulrike H MitchellBill Myrer
May 31, 2015·Zeitschrift für Gerontologie und Geriatrie·H Frohnhofen, J Schlitzer
Aug 2, 2011·Journal of Korean Academy of Nursing·Yeon-Gyung Bak, Hyoung-Sook Park
Jun 6, 2014·Sleep·Diego Garcia-BorregueroRichard P Allen
May 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Ralf KohnenMarco Zucconi
Jun 26, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Stephany Fulda, Thomas C Wetter
Dec 18, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Wayne A HeningRobert Yoakum
May 20, 2008·CNS Drugs·Pankaj Satija, William G Ondo
Sep 6, 2019·International Heart Journal·Akiomi YoshihisaYasuchika Takeishi
Sep 12, 2017·NPJ Parkinson's Disease·Miguel Rosa-GriloK Ray Chaudhuri

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