Modeling the Context-Dependent Associations between the Gut Microbiome, Its Environment, and Host Health

MBio
Thomas J Sharpton, Christopher A Gaulke

Abstract

Changes in the gut microbiome are often associated with disease. One of the major goals in microbiome research is determining which components of this complex system are responsible for the observed differences in health state. Most studies apply a reductionist approach, wherein individual organisms are evaluated independently of the surrounding context of the microbiome. While such methods have yielded valuable insights into the microbiome, they fail to identify patterns that may be obscured by contextual variation. A recent report by Schubert et al. [A. M. Schubert, H. Sinani, and P. D. Schloss, mBio 6(4):e00974-15, 2015, doi: 10.1128/mBio.00974-15] communicates an alternative approach to the study of the microbiome's association with host health. By coupling a multifactored experimental design with regression modeling, the authors are able to profile context-dependent changes in the microbiome and predict health status. This work underscores the value of incorporating model-based procedures into the investigation of the microbiome and illustrates the potential clinical transformations that may arise through their use.

References

Jan 18, 2008·The Journal of Infectious Diseases·Ju Young ChangVincent B Young
May 21, 2011·Science·Jeremiah J FaithJeffrey I Gordon
Mar 21, 2012·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Ciarán P Kelly
Jan 18, 2013·The New England Journal of Medicine·Els van NoodJosbert J Keller
Sep 11, 2013·Scientific Reports·Alexander StatnikovConstantin F Aliferis
Jan 15, 2014·PloS One·Mariel M FinucaneKatherine S Pollard
Apr 15, 2014·Journal of Molecular Biology·Vanni Bucci, Joao B Xavier
Jun 19, 2014·MBio·Anna M SeekatzVincent B Young
Jul 12, 2014·PloS One·Clara BelzerLynn Bry

❮ Previous
Next ❯

Citations

May 4, 2017·Current Medicinal Chemistry·Maria De AngelisMarco Gobbetti
Jul 19, 2017·Psychosomatic Medicine·Karl J Maier, Mustafa alʼAbsi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Gastroenterology
Chung Owyang, Gary D Wu
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Gary D Wu, James D Lewis
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Eliotte Hirshberg
© 2021 Meta ULC. All rights reserved