Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient

BMC Systems Biology
Jignesh H ParmarPedro Mendes

Abstract

Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative diseases. Here we test the hypothesis that hepcidin alone is able to regulate iron distribution in different dietary regimes in the mouse using a computational model of iron distribution calibrated with radioiron tracer data. A model was developed and calibrated to the data from adequate iron diet, which was able to simulate the iron distribution under a low iron diet. However simulation of high iron diet shows considerable deviations from the experimental data. Namely the model predicts more iron in red blood cells and less iron in the liver than what was observed in experiments. These results suggest that hepcidin alone is not sufficient to regulate iron homeostasis in high iron conditions and that other factors are important. The model was able to simulate...Continue Reading

References

Jan 1, 1980·Annual Review of Biochemistry·P Aisen, I Listowsky
Jan 1, 1982·Journal of Mathematical Biology·P C FranzoneM Stefanelli
Oct 1, 1981·The Biochemical Journal·J S Easterby
Sep 2, 1999·The New England Journal of Medicine·J K OlynykL W Powell
Mar 14, 2000·The Journal of Physiology·P ZhangM C Neville
Aug 1, 1955·The American Journal of Physiology·E CHAPPELLEC A FINCH
Aug 2, 2005·Cell Metabolism·Tomas Ganz
Aug 29, 2006·Journal of Theoretical Biology·Bert J Lao, Daniel T Kamei
Oct 13, 2006·Bioinformatics·Stefan HoopsUrsula Kummer
May 24, 2008·Public Health Nutrition·Erin McLeanBruno de Benoist
Aug 12, 2009·Nature Biotechnology·Nicolas Le NovèreHiroaki Kitano
Apr 16, 2010·The Journal of Biological Chemistry·Shaobin WangMing-Hui Zou
Aug 14, 2010·BMC Systems Biology·Tiago J S LopesJens G Reich
Nov 5, 2010·BMC Systems Biology·J Cristian SalgadoMarco T Nuñez
Feb 25, 2011·Blood·Tomas Ganz
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elena CorradiniJodie L Babitt
Feb 15, 2012·Haematologica·Yehonatan GottliebEsther G Meyron-Holtz
Apr 25, 2012·Journal of Mathematical Biology·Doris H FuertingerPeter Kotanko
Jun 22, 2012·Journal of the Academy of Nutrition and Dietetics·Lisa Tussing-HumphreysCarol Braunschweig
Mar 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohammad I SalehPeter Veng-Pedersen
Nov 19, 2013·PLoS Computational Biology·Simon Mitchell, Pedro Mendes
Jan 1, 2011·Pharmaceutics·Peter Geisser, Susanna Burckhardt
Nov 22, 2014·Nucleic Acids Research·Vijayalakshmi ChelliahCamille Laibe
Jul 15, 2015·Nature Reviews. Immunology·Tomas Ganz, Elizabeta Nemeth
Sep 28, 2015·BMC Systems Biology·Pierre MillardPedro Mendes
Oct 4, 2015·Trends in Genetics : TIG·Matthew F Barber, Nels C Elde

❮ Previous
Next ❯

Citations

Jan 5, 2019·PLoS Computational Biology·Jignesh H Parmar, Pedro Mendes
Mar 27, 2018·Biological Reviews of the Cambridge Philosophical Society·Douglas B Kell, Etheresia Pretorius
Sep 11, 2019·The Journal of Nutrition·Xiaoyu WangJames F Collins
Mar 18, 2020·Food Science & Nutrition·Meichen WangYumei Zhang
May 27, 2020·Scientific Reports·Sibylle Schirm, Markus Scholz

❮ Previous
Next ❯

Datasets Mentioned

BETA
MODEL1605030005

Software Mentioned

AdequateTracer
Cell Designer
COPASI
BioModels
Linux
Parmar2016
Inkscape
AdequateNoTracer

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

© 2022 Meta ULC. All rights reserved