Jul 8, 2016

Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient

BioRxiv : the Preprint Server for Biology
Jignesh H. ParmarPedro Mendes

Abstract

Background: Iron is an essential element of most living organisms but is a dangerous substance when poorly liganded in solution, as it can catalyze the generation of hydroxyl radical and strong evidence supports its involvement, combined with reactive oxygen species, in a wide range of diseases. The hormone hepcidin regulates the export of iron from tissues to the plasma contributing to iron homeostasis and also restricting its availability to infectious agents. Disruption of iron regulation in mammals leads to disorders such as anemia and hemochromatosis, and contributes to the etiology of several other diseases such as cancer and neurodegenerative diseases. Results: Here we develop a dynamic model of mouse iron distribution including regulation by hepcidin and use it to fit existing data from different diets. The model is able to fit data for adequate and low iron diets but has considerable deviations from the data for a rich iron diet. Namely the model predicts more iron in red blood cells and less iron in the liver than what was observed in experiments. Conclusions: The implication of these results is that hepcidin alone is not sufficient to regulate iron homeostasis in high iron conditions and that other factors are import...Continue Reading

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Mentioned in this Paper

Hepcidin
Diet
Hemochromatosis
Regulation of Biological Process
Hamp
Hydroxyl Radical
Red blood cells, blood product
Nerve Degeneration
HAMP
HAMP gene

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