Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons

Brain Structure & Function
C Ákos SzabóShalini Narayana

Abstract

The baboon provides a model of photosensitive, generalized epilepsy. This study compares cerebral blood flow responses during intermittent light stimulation (ILS) between photosensitive (PS) and healthy control (CTL) baboons using H 2 (15) O-PET. We examined effective connectivity associated with visual stimulation in both groups using structural equation modeling (SEM). Eight PS and six CTL baboons, matched for age, gender and weight, were classified on the basis of scalp EEG findings performed during the neuroimaging studies. Five H 2 (15) O-PET studies were acquired alternating between resting and activation (ILS at 25 Hz) scans. PET images were acquired in 3D mode and co-registered with MRI. SEM demonstrated differences in neural connectivity between PS and CTL groups during ILS that were not previously identified using traditional activation analyses. First-level pathways consisted of similar posterior-to-anterior projections in both groups. While second-level pathways were mainly lateralized to the left hemisphere in the CTL group, they consisted of bilateral anterior-to-posterior projections in the PS baboons. Third- and fourth-level pathways were only evident in PS baboons. This is the first functional neuroimaging stud...Continue Reading

References

Feb 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M A MintunM E Raichle
Dec 1, 1968·Electroencephalography and Clinical Neurophysiology·M Fischer-WilliamsR Naquet
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H ItoI Kanno
Jul 5, 2005·Epilepsy Research·C Akos SzabóJeff T Williams
Apr 20, 2006·Behavioural Brain Research·Adrien Meguerditchian, Jacques Vauclair
Feb 14, 2007·Epilepsia·C Akos SzabóJeff T Williams
Apr 5, 2008·NeuroImage·Angela R LairdPeter T Fox
Jul 22, 2009·NeuroImage·Friederike MoellerMichael Siniatchkin
Apr 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaoxiao BaiHal Blumenfeld
Jan 1, 2009·Structural Equation Modeling : a Multidisciplinary Journal·Larry R PriceRoger J Ingham
Jan 26, 2012·The Open Neuroimaging Journal·C Ákos SzabóShalini Narayana
Mar 19, 2013·Epilepsy Research·C Ákos SzabóJeff T Williams
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicole A YoungJon H Kaas

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Citations

Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Franziska WielaenderHannes Lohi

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