Modeling the effects of different infant feeding strategies on infant survival and mother-to-child transmission of HIV

American Journal of Public Health
Jay S Ross, Miriam H Labbok

Abstract

We investigated how, under various conditions, the risk of mother-to-child transmission of HIV through breastfeeding compares with the risk of death from artificial feeding. We developed a spreadsheet simulation model to predict HIV-free survival during 7 age intervals from 0 to 24 months for 5 different infant feeding scenarios in resource-poor settings. Compared with artificial feeding, breastfeeding during the first 6 months by HIV-positive mothers increases HIV-free survival by 32 per 1000 live births. After 6 months, as the age-specific mortality rate and risk of death caused by replacement feeding both decline, replacement feeding appears to be safer. Under conditions common in countries with high HIV prevalence, replacement feeding by HIV-infected mothers should not be generally encouraged until after the infant is approximately 6 months old.

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Citations

Nov 29, 2005·Seminars in Fetal & Neonatal Medicine·Adriano Cattaneo, Sofia Quintero-Romero
Sep 14, 2007·American Journal of Obstetrics and Gynecology·Tracy L CreekNathan Shaffer
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Oct 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tracy L CreekMargarett K Davis
Apr 18, 2009·Current Opinion in HIV and AIDS·Nigel Rollins, Wendy Mphatswe

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