Modeling the effects of fluoxetine on food-reinforced behavior

Behavioural Pharmacology
Federico SanabriaLewis A Bizo

Abstract

We propose a novel method to dissociate incentive motivation from memory and motor processes in instrumental performance. Components of a multiple fixed-ratio schedule of food reinforcement were adjusted to envelop the range of response requirements that maintained lever pressing by rats. We sought to manipulate motivation for food rewards with acute administrations of various doses (0-10 mg/kg) of fluoxetine, a 5-HT reuptake inhibitor that reduces food intake. A quantitative model of fixed-ratio performance derived from Killeen's (1994) Mathematical Principles of Reinforcement (MPR) provided an adequate account of data from individual rats. Decreases in response rate resulting from fluoxetine were reflected in changes in estimates of activation, indexed by MPR parameter a; estimates of working memory capacity and lever pressing duration were not systematically affected. These results support the use of MPR parameter a to index incentive motivation using multiple fixed-ratio schedules that are adjusted to individual performance.

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Citations

Jan 23, 2009·Journal of Experimental Psychology. Animal Behavior Processes·Peter R KilleenEric A Thrailkill
Jan 10, 2014·Psychopharmacology·Lourdes Valencia-TorresVladimir Orduña
Dec 17, 2008·Behavioural Brain Research·Irene AvilaEddie Castañeda
Mar 4, 2014·Journal of the Experimental Analysis of Behavior·Raymond C Pitts
Feb 26, 2010·Social Issues and Policy Review·Jennifer L HarrisJohn A Bargh
Jul 19, 2011·Journal of the Experimental Analysis of Behavior·Ryan J BrackneyFederico Sanabria
Feb 23, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gabriel Araújo TavaresSandra Lopes de Souza
Jun 30, 2019·Journal of the Experimental Analysis of Behavior·Julie-Anne M BruceT Mary Foster
Feb 26, 2021·Learning & Behavior·Ryan J BrackneyFederico Sanabria
Nov 5, 2016·Neurotoxicology·Steven R Boomhower, M Christopher Newland

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