Modeling the Efficacy of Oncolytic Adenoviruses In Vitro and In Vivo: Current and Future Perspectives.

Cancers
Mary K McKennaMasataka Suzuki

Abstract

Oncolytic adenoviruses (OAd) selectively target and lyse tumor cells and enhance anti- tumor immune responses. OAds have been used as promising cancer gene therapies for many years and there are a multitude of encouraging pre-clinical studies. However, translating OAd therapies to the clinic has had limited success, in part due to the lack of realistic pre-clinical models to rigorously test the efficacy of OAds. Solid tumors have a heterogenous and hostile microenvironment that provides many barriers to OAd treatment, including structural and immunosuppressive components that cannot be modeled in two-dimensional tissue culture. To replicate these characteristics and bridge the gap between pre-clinical and clinical success, studies must test OAd therapy in three-dimensional culture and animal models. This review focuses on current methods to test OAd efficacy in vitro and in vivo and the development of new model systems to test both oncolysis and immune stimulatory components of oncolytic adenovirotherapy.

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Citations

Oct 30, 2020·Cancers·Mizuho Sato-DahlmanMasato Yamamoto
Feb 12, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mary K McKennaMalcolm K Brenner

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Methods Mentioned

BETA
xenograft
biopsies
xenografts

Clinical Trials Mentioned

NCT02705196
NCT01598129

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