Modeling the emergence of whisker direction maps in rat barrel cortex.

PloS One
Stuart P WilsonJames A Bednar

Abstract

Based on measuring responses to rat whiskers as they are mechanically stimulated, one recent study suggests that barrel-related areas in layer 2/3 rat primary somatosensory cortex (S1) contain a pinwheel map of whisker motion directions. Because this map is reminiscent of topographic organization for visual direction in primary visual cortex (V1) of higher mammals, we asked whether the S1 pinwheels could be explained by an input-driven developmental process as is often suggested for V1. We developed a computational model to capture how whisker stimuli are conveyed to supragranular S1, and simulate lateral cortical interactions using an established self-organizing algorithm. Inputs to the model each represent the deflection of a subset of 25 whiskers as they are contacted by a moving stimulus object. The subset of deflected whiskers corresponds with the shape of the stimulus, and the deflection direction corresponds with the movement direction of the stimulus. If these two features of the inputs are correlated during the training of the model, a somatotopically aligned map of direction emerges for each whisker in S1. Predictions of the model that are immediately testable include (1) that somatotopic pinwheel maps of whisker dire...Continue Reading

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Citations

Oct 25, 2011·PLoS Computational Biology·Stuart P WilsonBen Mitchinson
Jan 16, 2014·Cognitive Neurodynamics·Steven Ravett Brown
Dec 12, 2012·The Biochemical Journal·Annette LashamAntony W Braithwaite
Mar 4, 2014·PloS One·Cengiz Pehlevan, Haim Sompolinsky
Nov 5, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James A Bednar, Stuart P Wilson
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
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Dec 2, 2020·Journal of Mathematical Neuroscience·Georgios DetorakisNicolas P Rougier
Jul 3, 2021·Frontiers in Computational Neuroscience·Bhadra S KumarS Pushpavanam

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Software Mentioned

LISSOM ( Interconnected Synergetically Self - Organizing Map
LISSOM
Topographica simulator

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Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.