PMID: 12765406May 27, 2003Paper

Modeling the frequency dependence (5-120 MHz) of ultrasound backscattering by red cell aggregates in shear flow at a normal hematocrit

The Journal of the Acoustical Society of America
Isabelle Fontaine, Guy Cloutier

Abstract

The frequency dependence of the ultrasound signal backscattered by blood in shear flow was studied using a simulation model. The ultrasound backscattered signal was computed with a linear model that considers the characteristics of the ultrasound system and tissue acoustic properties. The tissue scattering properties were related to the position and shape of the red blood cells (RBCs). A 2D microrheological model simulated the RBC dynamics in a Couette shear flow system. This iterative model, described earlier [Biophys. J. 82, 1696-1710 (2002)], integrates the hydrodynamic effect of the flow, as well as adhesive and repulsive forces between RBCs. RBC aggregation was simulated at 40% hematocrit and shear rates of 0.05-2 s(-1). The RBC aggregate sizes ranged, on average, from 3.3 RBCs at 2 s(-1) to 33.5 cells at 0.05 s(-1). The ultrasound backscattered power was studied at frequencies between 5-120 MHz and insonification angles between 0-180 degrees. At frequencies below approximately 30 MHz, the ultrasound backscattered power increased as the shear rate was decreased and the size of the aggregates was raised. A totally different scattering behavior was noted above 30 MHz. Typical spectral slopes of the backscattered power (log-l...Continue Reading

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Citations

Jul 7, 2007·The Journal of the Acoustical Society of America·François T H Yu, Guy Cloutier
Dec 14, 2007·Ultrasound in Medicine & Biology·Rachel Libgot-CalléFrédéric Patat
Jan 12, 2008·Ultrasound in Medicine & Biology·Linh Chi NguyenGuy Cloutier
Jun 26, 2007·Ultrasound in Medicine & Biology·Damien GarciaGuy Cloutier
Dec 1, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emilie FranceschiniGuy Cloutier
Mar 4, 2005·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·David Savéry, Guy Cloutier
Aug 7, 2004·The Journal of the Acoustical Society of America·Guy CloutierF Stuart Foster
Sep 1, 2018·Journal of Medical Ultrasonics·Hiroki SakakiHiroshi Kanai

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