Modeling the Genetic Basis of Individual Differences in Susceptibility to Gulf War Illness

Brain Sciences
Byron C JonesJames P O'Callaghan

Abstract

Between 25% and 30% of the nearly one million military personnel who participated in the 1991 Persian Gulf War became ill with chronic symptoms ranging from gastrointestinal to nervous system dysfunction. This disorder is now referred to as Gulf War Illness (GWI) and the underlying pathophysiology has been linked to exposure-based neuroinflammation caused by organophosphorous (OP) compounds coupled with high circulating glucocorticoids. In a mouse model of GWI we developed, corticosterone was shown to act synergistically with an OP (diisopropylflurophosphate) to dramatically increase proinflammatory cytokine gene expression in the brain. Because not all Gulf War participants became sick, the question arises as to whether differential genetic constitution might underlie individual differences in susceptibility. To address this question of genetic liability, we tested the impact of OP and glucocorticoid exposure in a genetic reference population of 30 inbred mouse strains. We also studied both sexes. The results showed wide differences among strains and overall that females were less sensitive to the combined treatment than males. Furthermore, we identified one OP-glucocorticoid locus and nominated a candidate gene-Spon1-that may...Continue Reading

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Citations

Jun 24, 2020·Brain, Behavior, and Immunity·Fuyi XuLu Lu
Jun 26, 2021·Pharmacology & Therapeutics·Ana C R Ribeiro, Laxmikant S Deshpande
Aug 28, 2021·International Journal of Molecular Sciences·Francisco J Carrera AriasTravis J A Craddock

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Methods Mentioned

BETA
PCR
RNA-seq

Software Mentioned

GeneNetwork
GN1

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