Modeling the Impact of Microgravity at the Cellular Level: Implications for Human Disease

Frontiers in Cell and Developmental Biology
Peta BradburyJoshua Chou

Abstract

A lack of gravity experienced during space flight has been shown to have profound effects on human physiology including muscle atrophy, reductions in bone density and immune function, and endocrine disorders. At present, these physiological changes present major obstacles to long-term space missions. What is not clear is which pathophysiological disruptions reflect changes at the cellular level versus changes that occur due to the impact of weightlessness on the entire body. This review focuses on current research investigating the impact of microgravity at the cellular level including cellular morphology, proliferation, and adhesion. As direct research in space is currently cost prohibitive, we describe here the use of microgravity simulators for studies at the cellular level. Such instruments provide valuable tools for cost-effective research to better discern the impact of weightlessness on cellular function. Despite recent advances in understanding the relationship between extracellular forces and cell behavior, very little is understood about cellular biology and mechanotransduction under microgravity conditions. This review will examine recent insights into the impact of simulated microgravity on cell biology and how this...Continue Reading

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Citations

Dec 2, 2020·International Journal of Molecular Sciences·Alessandra CazzanigaJeanette A Maier
Jan 13, 2021·Life·Patricia Fajardo-Cavazos, Wayne L Nicholson
Mar 9, 2021·Journal of Chemical Information and Modeling·Barnali Das, Pralay Mitra
Apr 4, 2021·International Journal of Molecular Sciences·Victor CamberosMary Kearns-Jonker
May 1, 2021·International Journal of Molecular Sciences·Shirley GenahLucia Morbidelli
May 1, 2021·Pathogens·Marta Filipa Simões, André Antunes
May 20, 2021·Stem Cells International·Uğur Topal, Cihan Zamur
Aug 28, 2021·Journal of Mammary Gland Biology and Neoplasia·Gina ReyeHonor J Hugo
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Jul 6, 2021·Artificial Organs·Vishal SwaminathanVakhtang Tchantchaleishvili

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