Modeling the long-term persistence of hepatitis A antibody after a two-dose vaccination schedule in Argentinean children

The Pediatric Infectious Disease Journal
Eduardo L LópezJudith Armoni

Abstract

Long-term seroprotection data are essential for decision-making on the need and timing of vaccine boosters. Based on data from longitudinal serological studies, modeling can provide estimates on long-term antibody persistence and inform such decision-making. We examined long-term anti-hepatitis A virus (anti-HAV) antibody persistence in Argentinean children ≤15 years after the initial study where they completed a 2-dose course of inactivated hepatitis A vaccine (Avaxim 80U Pediatric, Sanofi Pasteur, Lyon, France). Blood serum samples were taken at baseline, 2 weeks (post first dose), 6 months (pre-booster), 6.5 months (post-booster), 10 years and 14-15 years after first vaccine dose. We fitted 8 statistical model types, predominantly mixed effects models, to anti-HAV persistence data, to identify the most appropriate and best fitting models for our data set and to predict individuals' anti-HAV levels and seroprotection rates up to 30 years post vaccination. Fifty-four children (mean age at enrollment 30.4 months) were enrolled up to 15 years post first vaccine dose. There were 3 distinct periods of antibody concentration: rapid rise up to peak concentration post-booster, rapid decay from post-booster to 10 years, followed by sl...Continue Reading

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Citations

Oct 4, 2016·Pediatrics in Review·John C Christenson, John J Manaloor
Oct 28, 2016·Human Vaccines & Immunotherapeutics·Anke L StuurmanDaniel Shouval
Feb 27, 2019·Expert Review of Vaccines·Catherine BravoYael Thollot
Jul 24, 2015·Current Opinion in Infectious Diseases·Rakesh Aggarwal, Amit Goel
Dec 17, 2020·Human Vaccines & Immunotherapeutics·Christian HerzogPierre Van Damme
Jul 3, 2019·Vaccine·Anthony AlmudevarMichael Pichichero
Dec 1, 2020·Journal of Virus Eradication·Nawarat PosuwanYong Poovorawan
May 1, 2021·Vaccines·Ana Luiza BierrenbachThais das Neves Fraga Moreira

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