Modeling the Notch Response

Advances in Experimental Medicine and Biology
Udi Binshtok, David Sprinzak

Abstract

NOTCH signaling regulates developmental processes in all tissues and all organisms across the animal kingdom. It is often involved in coordinating the differentiation of neighboring cells into different cell types. As our knowledge on the structural, molecular and cellular properties of the NOTCH pathway expands, there is a greater need for quantitative methodologies to get a better understanding of the processes controlled by NOTCH signaling. In recent years, theoretical and computational approaches to NOTCH signaling and NOTCH mediated patterning are gaining popularity. Mathematical models of NOTCH mediated patterning provide insight into complex and counterintuitive behaviors and can help generate predictions that can guide experiments. In this chapter, we review the recent advances in modeling NOTCH mediated patterning processes. We discuss new modeling approaches to lateral inhibition patterning that take into account cis-interactions between NOTCH receptors and ligands, signaling through long cellular protrusions, cell division processes, and coupling to external signals. We also describe models of somitogenesis, where NOTCH signaling is used for synchronizing cellular oscillations. We then discuss modeling approaches tha...Continue Reading

Citations

Sep 10, 2020·Cells·María-Milagros Rodríguez-CanoVictoriano Baladrón
Oct 21, 2020·Physical Review. E·J M Sancho, Marta Ibañes
Nov 20, 2020·Physical Biology·Nicola Mulberry, Leah Edelstein-Keshet
Jan 7, 2021·Tissue Engineering. Part C, Methods·Tommaso RistoriCecilia M Sahlgren
Jan 15, 2021·Journal of Cell Science·Oscar M J A StassenCecilia M Sahlgren
Jul 10, 2021·Biophysical Journal·Roie Cohen, David Sprinzak
Sep 28, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chengjian ZhaoP Duc Si Dong

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