Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis

Schizophrenia Research
Danielle A SchlosserSophia Vinogradov

Abstract

A priority for improving outcome in individuals at clinical high risk (CHR) is enhancing our understanding of predictors of psychosis as well as psychosocial functioning. Social functioning, in particular, is a unique indicator of risk as well as an important outcome in itself. Negative symptoms are a significant determinant of social functioning in CHR individuals; yet, it is unclear which specific negative symptoms drive functional outcome and how these symptoms function relative to other predictors, such as neurocognition and mood/anxiety symptoms. In a sample of 85 CHR individuals, we examined whether a two-factor negative symptom structure that is found in schizophrenia (experiential vs expressive symptoms) would be replicated in a CHR sample; and tested the degree to which specific negative symptoms predict social functioning, relative to neurocognition and mood/anxiety symptoms, which are known to predict functioning. The two-factor negative symptom solution was replicated in this CHR sample. Negative symptom severity was found to be uniquely predictive of social functioning, above and beyond depression/anxiety and neurocognition. Experiential symptoms were more strongly associated with social functioning, relative to ex...Continue Reading

References

Sep 23, 2016·Early Intervention in Psychiatry·Marleine AzarMartin Lepage
Jun 8, 2017·The Australian and New Zealand Journal of Psychiatry·TianHong ZhangJiJun Wang
Feb 18, 2017·Current Opinion in Psychiatry·P Bucci, S Galderisi
Jul 20, 2017·The British Journal of Clinical Psychology·Genevieve A DingleJonathon Welch
Jul 25, 2018·Early Intervention in Psychiatry·Lauren E BrookeDaniel F Gucciardi
Oct 26, 2018·Harvard Review of Psychiatry·Geneviève SauvéMartin Lepage
Oct 18, 2019·Acta Psychiatrica Scandinavica·Louise Birkedal GlenthøjMerete Nordentoft
Jan 8, 2020·Early Intervention in Psychiatry·Louise Birkedal GlenthøjMerete Nordentoft
Jun 26, 2018·Early Intervention in Psychiatry·Daniel J DevoeJean Addington
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Charlotte A ChunLauren M Ellman
Jun 1, 2017·NPJ Schizophrenia·Louise Birkedal GlenthøjMerete Nordentoft
Jul 10, 2018·Acta Psychiatrica Scandinavica·P BucciItalian Network for Research on Psychoses
Dec 12, 2018·Schizophrenia Bulletin·Matilda AzisVijay Mittal

Citations

Oct 29, 2005·Schizophrenia Bulletin·Jack J Blanchard, Alex S Cohen
Jan 9, 2008·Archives of General Psychiatry·Tyrone D CannonRobert Heinssen
Jul 23, 2008·Schizophrenia Bulletin·George Foussias, Gary Remington
May 21, 2010·Psychological Medicine·Y RassovskyMichael F Green
Apr 19, 2011·The American Journal of Psychiatry·Jean AddingtonRobert Heinssen
May 4, 2011·The American Journal of Psychiatry·Ricardo E CarriónBarbara A Cornblatt
Nov 15, 2011·Schizophrenia Bulletin·Barbara A CornblattTodd Lencz
Jan 11, 2012·The Journal of Neuropsychiatry and Clinical Neurosciences·Ali EslamiKristin S Cadenhead
Mar 7, 2012·Archives of General Psychiatry·Paolo Fusar-PoliPhilip McGuire
Mar 27, 2012·Psychiatry Research·Danijela PiskulicThomas H McGlashan
Oct 3, 2012·Archives of General Psychiatry·Michael F GreenJonathan K Wynn
Feb 5, 2013·The American Journal of Psychiatry·Ann M KringSteven P Reise
Jul 11, 2014·Schizophrenia Research·Danielle A SchlosserSophia Vinogradov
Dec 6, 2014·Frontiers in Behavioral Neuroscience·Diana WotrubaStefan Kaiser

Related Concepts

Individual Adjustment
High-Risk Cancer
Schizophrenia
Depressed - Symptom
Chronic Disease
5'-Inosinic acid, 2'-deoxy-2'-fluoro-, homopolymer
Poly A
Social Behavior Disorders
Experience
Zellweger Syndrome

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.