Modeling the spontaneous activity of the auditory cortex

Journal of Computational Neuroscience
E BartD Holcman

Abstract

We present a rate model of the spontaneous activity in the auditory cortex, based on synaptic depression. A Stochastic integro-differential system of equations is derived and the analysis reveals two main regimes. The first regime corresponds to a normal activity. The second regime corresponds to epileptic spiking. A detailed analysis of each regime is presented and we prove in particular that synaptic depression stabilizes the global cortical dynamics. The transition between the two regimes is induced by a change in synaptic connectivity: when the overall connectivity is strong enough, an epileptic activity is spontaneously generated. Numerical simulations confirm the predictions of the theoretical analysis. In particular, our results explain the transition from normal to epileptic regime which can be induced in rats auditory cortex, following a specific pairing protocol. A change in the cortical maps reorganizes the synaptic connectivity and this transition between regimes is accounted for by our model. We have used data from recording experiments to fit synaptic weight distributions. Simulations with the fitted distributions are qualitatively similar to the real EEG recorded in vivo during the experiments. We conclude that c...Continue Reading

References

Jan 1, 1972·Biophysical Journal·H R Wilson, J D Cowan
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·M V Tsodyks, H Markram
Mar 28, 1998·Science·M P Kilgard, M M Merzenich
Apr 8, 1998·Annual Review of Neuroscience·D V Buonomano, M M Merzenich
Jun 6, 1998·Neural Computation·M TsodyksH Markram
Dec 29, 2000·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·N N Byl, A McKenzie
Sep 7, 2002·Journal of Computational Neuroscience·Alex Loebel, Misha Tsodyks
Feb 20, 2003·Somatosensory & Motor Research·David T BlakeMichael Merzenich
May 16, 2003·Nature·Rosa CossartRafael Yuste
May 16, 2003·Nature·Yousheng ShuDavid A McCormick
Aug 3, 2004·Nature Neuroscience·Shaowen BaoMichael M Merzenich

❮ Previous
Next ❯

Citations

Oct 30, 2009·Journal of Computational Neuroscience·Zachary P Kilpatrick, Paul C Bressloff
Jul 13, 2011·Journal of Computational Neuroscience·Paul C Bressloff, Matthew A Webber
Mar 25, 2006·PLoS Computational Biology·David Holcman, Misha Tsodyks
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Claire GuerrierDavid Holcman
Aug 19, 2015·Frontiers in Computational Neuroscience·Khanh Dao DucDavid Holcman
Nov 28, 2012·Communicative & Integrative Biology·Dominik FrecheDavid Holcman
Feb 18, 2015·PLoS Computational Biology·Laura R González-RamírezMark A Kramer
Jul 7, 2015·BioMed Research International·Eman M Rabie Shehab El-DinRamadan Hassan
Sep 12, 2020·Journal of Mathematical Neuroscience·Bolun Chen, Paul Miller
Mar 15, 2016·Journal of Mathematical Biology·Zachary T McCleney, Zachary P Kilpatrick
Dec 7, 2021·PLoS Computational Biology·Lou Zonca, David Holcman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M V Tsodyks, H Markram
Neural Computation
Jan Benda, Andreas V M Herz
Proceedings of the National Academy of Sciences of the United States of America
M StockerP Pedarzani
© 2021 Meta ULC. All rights reserved