Modeling the statistics of elementary calcium release events

Biophysical Journal
Ghanim Ullah, Peter Jung

Abstract

Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the release of Ca(2+) from endoplasmic reticulum through small clusters of inositol 1,4,5-trisphosphate receptors, are the building blocks for intracellular Ca(2+) signaling. The small number of release channels involved during a Ca(2+) puff renders the puffs stochastic, with distributed amplitudes, durations, and frequency, well characterized experimentally. We present a stochastic model that accurately describes simultaneously the statistical properties of the duration, amplitudes, frequencies, and spatial spread with a single set of parameters.

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Citations

Jun 6, 2009·Journal of Biomolecular Structure & Dynamics·George PatargiasWolfgang B Fischer
Oct 2, 2009·Chaos·R ThulM Falcke
Oct 2, 2009·Chaos·D SwaminathanP Jung
Jun 12, 2012·Cell Calcium·Ghanim UllahJohn E Pearson
Apr 8, 2009·Journal of Theoretical Biology·Erin R HigginsMartin Falcke
Mar 14, 2007·Cell Calcium·Ghanim UllahKhaled Machaca
May 21, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J W ShuaiS Rüdiger
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ana CalabreseSilvina Ponce Dawson
Jan 31, 2014·Physical Biology·Daniel Fraiman, Silvina Ponce Dawson
Nov 13, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G SoloveyS Ponce Dawson
Sep 25, 2018·Cell Calcium·Patrick TogliaGhanim Ullah
Sep 28, 2010·Physical Review Letters·S RüdigerI M Sokolov
Jul 5, 2018·Biophysical Journal·Syed Islamuddin ShahGhanim Ullah

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