Modeling the Structure of Keratin 1 and 10 Terminal Domains and their Misassembly in Keratoderma

The Journal of Investigative Dermatology
Cedric BadowskiE B Lane

Abstract

The terminal domains of suprabasal keratins of the skin epithelium are very resistant to evidence-based structural analysis because of their inherent flexibility and lack of predictable structure. We present a model for the structure and interactions of the head and tail domains of epidermal keratins 1 and 10, based on all-atom 3D simulations of keratin primary amino acid sequences, and tyrosine phosphorylation predictions, extracted from published databases. We observed that keratin 1 and 10 end domains are likely to form a tetrameric terminal domain complex incorporating a reversibly extendable region potentially acting as a molecular spring. This structure is formed by intermolecular stacking of aromatic residues, which would spatially constrain the keratin 1/keratin 10 end domains to allow filament compaction and bundling, whilst also retaining extensibility to ensure flexibility of the keratin filament network in the differentiating epidermis. The tetrameric terminal domain complex model may also help to elucidate the effects of mutations in the end domains of suprabasal keratins and so contribute to understanding of the mechanisms leading to keratinopathies such as striate palmoplantar keratoderma, as reported in this study.

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B P KorgeP M Steinert
Jan 1, 1988·Annual Review of Biochemistry·P M Steinert, D R Roop
Jun 23, 1998·The Journal of Biological Chemistry·G B McGaugheyA K Rappé
Mar 19, 1999·European Journal of Cell Biology·J M Paramio
May 2, 2002·The Journal of Investigative Dermatology·Neil V WhittockJohn A McGrath
Mar 20, 2003·Angewandte Chemie·Emmanuel A MeyerFrançois Diederich
Mar 25, 2005·Nucleic Acids Research·Pierre MignonPaul Geerlings
Jun 20, 2006·Trends in Biochemical Sciences·M Bishr OmaryJian Liao
May 21, 2008·International Journal of Cosmetic Science·L Norlén
May 15, 2012·Journal of Chemical Theory and Computation·Andreas W GötzRoss C Walker
Oct 22, 2014·Molecular and Cellular Biology·Afnan Abu-ThuraiaJean-François Côté

❮ Previous
Next ❯

Citations

Dec 7, 2018·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·N Martínez-MicaeloL Masana
Nov 16, 2020·Current Opinion in Cell Biology·Sherif A EldiranyChristopher G Bunick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology Online Journal
Katherine L White
The Journal of Dermatology
Kazuhiro KawaiTakuro Kanekura
Clinical and Experimental Dermatology
D HershkovitzE Sprecher
The Journal of Investigative Dermatology
Meral J ArinD R Roop
© 2022 Meta ULC. All rights reserved