Modeling Three-Dimensional Structural Motifs of Viral IRES

Journal of Molecular Biology
Gloria LozanoEncarnación Martínez-Salas

Abstract

RNA virus genomes are reservoirs of a wide diversity of RNA structural elements. In particular, specific regions of the viral genome have evolved to adopt specialized three-dimensional (3D) structures, which can act in concert with host factors and/or viral proteins to recruit the translation machinery on viral RNA using a mechanism that is independent on the 5' end. This strategy relies on cis-acting RNA sequences designated as internal ribosome entry site (IRES) elements. IRES elements that are found in the genome of different groups of RNA viruses perform the same function despite differing in primary sequence and secondary RNA structure and host factor requirement to recruit the translation machinery internally. Evolutionarily conserved motifs tend to preserve sequences in each group of RNA viruses impacting on RNA structure and RNA-protein interactions important for IRES function. However, due to the lack of sequence homology among genetically distant IRES elements, accurate modeling of 3D IRES structure is currently a challenging task. In addition, as a universal RNA motif unique to IRES elements has not been found, a better understanding of viral IRES structural motifs could greatly assist in the detection of IRES-like m...Continue Reading

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Citations

Feb 16, 2016·Journal of Molecular Biology·Anna Marie Pyle, Tamar Schlick
Jan 19, 2019·Life Science Alliance·Javier Fernandez-ChamorroEncarnación Martinez-Salas
Oct 24, 2017·Archives of Virology·Roland Zell
Jan 23, 2018·Frontiers in Microbiology·Chun Shen Lim, Chris M Brown
Sep 25, 2018·Nucleic Acids Research·Zhaolong LiWenyan Zhang
Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miguel MorenoCarlos Briones
Aug 1, 2019·BMC Bioinformatics·Junhui Wang, Michael Gribskov
Dec 2, 2017·Wiley Interdisciplinary Reviews. RNA·Justine Mailliot, Franck Martin
Jan 23, 2018·Frontiers in Microbiology·Encarnacion Martinez-SalasAzman M Embarek
Nov 27, 2021·Nanoscale·Jiazhen LyuZhen Huang

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