A general model of neural development is derived to fit 18 mammalian species, including humans, macaques, several rodent species, and six metatherian (marsupial) mammals. The goal of this work is to describe heterochronic changes in brain evolution within its basic developmental allometry, and provide an empirical basis to recognize equivalent maturational states across animals. The empirical data generating the model comprises 271 developmental events, including measures of initial neurogenesis, axon extension, establishment, and refinement of connectivity, as well as later events such as myelin formation, growth of brain volume, and early behavioral milestones, to the third year of human postnatal life. The progress of neural events across species is sufficiently predictable that a single model can be used to predict the timing of all events in all species, with a correlation of modeled values to empirical data of 0.9929. Each species' rate of progress through the event scale, described by a regression equation predicting duration of development in days, is highly correlated with adult brain size. Neural heterochrony can be seen in selective delay of retinogenesis in the cat, associated with greater numbers of rods in its ret...Continue Reading
Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon
Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome
Scaling of neuron number and volume of the pulvinar complex in New World primates: comparisons with humans, other primates, and mammals
Embracing covariation in brain evolution: large brains, extended development, and flexible primate social systems
Monogamous and promiscuous rodent species exhibit discrete variation in the size of the medial prefrontal cortex
Resolving conflict in eutherian mammal phylogeny using phylogenomics and the multispecies coalescent model
Comparative analyses of evolutionary rates reveal different pathways to encephalization in bats, carnivorans, and primates
Cell size anomalies in the auditory thalamus of rats with hypoxic-ischemic injury on postnatal day 3 or 7
Possible role of GABAergic depolarization in neocortical neurons in generating hyperexcitatory behaviors during emergence from sevoflurane anesthesia in the rat
NSF workshop report: discovering general principles of nervous system organization by comparing brain maps across species
Analysis of extinction acquisition to attenuated tones in prenatally stressed and non-stressed offspring following auditory fear conditioning
Quantitative comparison of cerebral artery development in metatherians and monotremes with non-human eutherians
Evolution of cytoarchitectural landscapes in the mammalian isocortex: Sirenians (Trichechus manatus) in comparison with other mammals
Sensitive and critical periods during neurotypical and aberrant neurodevelopment: a framework for neurodevelopmental disorders
Ketamine exposure during embryogenesis inhibits cellular proliferation in rat fetal cortical neurogenic regions
When mothering goes awry: Challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving
Effects of Sex and Mild Intrainsult Hypothermia on Neuropathology and Neural Reorganization following Neonatal Hypoxic Ischemic Brain Injury in Rats
What lessons for clinical practice can be learned from systematic reviews of animal studies? The case of anesthetic neurotoxicity
Characterization of Laminar Zones in the Mid-Gestation Primate Brain with Magnetic Resonance Imaging and Histological Methods
Scaling the primate lateral geniculate nucleus: niche and neurodevelopment in the regulation of magnocellular and parvocellular cell number and nucleus volume
NSF workshop report: discovering general principles of nervous system organization by comparing brain maps across species
Dysmorphogenic effects of first trimester-equivalent ethanol exposure in mice: a magnetic resonance microscopy-based study
Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit
Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex
2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.
Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice
Removal of high-fat diet after chronic exposure drives binge behavior and dopaminergic dysregulation in female mice
Sevoflurane exposure during the neonatal period induces long-term memory impairment but not autism-like behaviors
Early life inflammatory pain induces long-lasting deficits in hippocampal-dependent spatial memory in male and female rats
Evolutionary relevance and experience contribute to face discrimination in infant macaques (Macaca mulatta )
Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors
A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis
Long-term dysregulation of brain corticotrophin and glucocorticoid receptors and stress reactivity by single early-life pain experience in male and female rats
Distinct neurobehavioral dysfunction based on the timing of developmental binge-like alcohol exposure
Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
The domestic piglet: an important model for investigating the neurodevelopmental consequences of early life insults
Dysregulated nitric oxide signaling as a candidate mechanism of fragile X syndrome and other neuropsychiatric disorders
Species extrapolation of life-stage physiologically-based pharmacokinetic (PBPK) models to investigate the developmental toxicology of ethanol using in vitro to in vivo (IVIVE) methods
Severity and timing: How prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring
Experimental Infection of Sheep at 45 and 60 Days of Gestation with Schmallenberg Virus Readily Led to Placental Colonization without Causing Congenital Malformations
Maternal separation prior to neonatal hypoxia-ischemia: Impact on emotional aspects of behavior and markers of synaptic plasticity in hippocampus
Neonatal Prefrontal Inactivation Results in Reversed Dopaminergic Responses in the Shell Subregion of the Nucleus Accumbens to NMDA Antagonists
mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats with both Tsc2 haploinsufficiency and developmental status epilepticus
Mechanisms involved in the neurotoxic and cognitive effects of developmental methamphetamine exposure
Dopamine is Required for Activity-Dependent Amplification of Arc mRNA in Developing Postnatal Frontal Cortex
Effects of immune activation during early or late gestation on schizophrenia-related behaviour in adult rat offspring
Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome
Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure
Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells
Principles of Network Architecture Emerging from Comparisons of the Cerebral Cortex in Large and Small Brains
Tyrosine hydroxylase-immunoreactivity and its relations with gonadotropin-releasing hormone and neuropeptide Y in the preoptic area of the guinea pig
Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development
Suboptimal nutrition in early life affects the inflammatory gene expression profile and behavioral responses to stressors
The ontogenetic development of neurons containing calcium-binding proteins in the septum of the guinea pig: Late onset of parvalbumin immunoreactivity versus calbindin and calretinin
Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats
Combining diffusion magnetic resonance tractography with stereology highlights increased cross-cortical integration in primates
Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity
Fetal Alcohol Exposure Alters Blood Flow and Neurological Responses to Transient Cerebral Ischemia in Adult Mice
Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood
Sex-dependent effects of early life inflammatory pain on sucrose intake and sucrose-associated hippocampal Arc expression in adult rats
Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain
Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism
BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action
Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice
Nicotine ameliorates schizophrenia-like cognitive deficits induced by maternal LPS exposure: a study in rats
Extrapolating evidence of antiepileptic drug efficacy in adults to children ≥2 years of age with focal seizures: The case for disease similarity
Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice
Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic melanocortin signaling in nonhuman primate offspring
Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5
Evaluating the effects of maternal alcohol consumption on murine fetal brain vasculature using optical coherence tomography
Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring
Endocranial Development in the Coyote (Canis latrans) and Gray Wolf (Canis lupus): A Computed Tomographic Study
Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies
Does pediatric anesthesia cause brain damage? - Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data
Prenatal two-hit stress affects maternal and offspring pregnancy outcomes and uterine gene expression in rats: match or mismatch?
Effects of binge ethanol exposure during first-trimester equivalent on corticothalamic neurons in Swiss Webster outbred mice
Next-Generation Sequencing Identifies Polyunsaturated Fatty Acid Responsive Genes in the Juvenile Rat Cerebellum
Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children
Evolution of Brain Connections: Integrating Diffusion MR Tractography With Gene Expression Highlights Increased Corticocortical Projections in Primates
Magnetic Resonance Imaging Findings of Term and Preterm Hypoxic-Ischemic Encephalopathy: A Review of Relevant Animal Models and Correlation to Human Imaging
Frequent nonrandom shifts in the temporal sequence of developmental landmark events during teleost evolutionary diversification
Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse
Newly Generated and Non-Newly Generated "Immature" Neurons in the Mammalian Brain: A Possible Reservoir of Young Cells to Prevent Brain Aging and Disease?
Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams
Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner.
Postweaning Iron Deficiency in Male Rats Leads to Long-Term Hyperactivity and Decreased Reelin Gene Expression in the Nucleus Accumbens
High Angular Resolution Diffusion MRI Reveals Conserved and Deviant Programs in the Paths that Guide Human Cortical Circuitry
Reciprocal F1 Hybrids of Two Inbred Mouse Strains Reveal Parent-of-Origin and Perinatal Diet Effects on Behavior and Expression
Impairment of the Developing Human Brain in Iron Deficiency: Correlations to Findings in Experimental Animals and Prospects for Early Intervention Therapy
Developmental Vitamin D Deficiency in the Rat Impairs Recognition Memory, but Has No Effect on Social Approach or Hedonia
Multiple sevoflurane exposures during pregnancy inhibit neuronal migration by upregulating prostaglandin D2 synthase
Gestational folic acid supplementation does not affects the maternal behavior and the early development of rats submitted to neonatal hypoxia-ischemia but the high supplementation impairs the dam's memory and the Na+ , K+ - ATPase activity in the pup's hippocampus
Behavioral and neuroanatomical outcomes in a rat model of preterm hypoxic-ischemic brain Injury: Effects of caffeine and hypothermia
Developmental duration as an organizer of the evolving mammalian brain: scaling, adaptations, and exceptions
Why considering sexual differences is necessary when studying encephalopathy of prematurity through rodent models.
In-vivo hemodynamic imaging of acute prenatal ethanol exposure in fetal brain by photoacoustic tomography.
In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography
Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols
Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity
Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
Development of body, head and brain features in the Australian fat-tailed dunnart (Sminthopsis crassicaudata; Marsupialia: Dasyuridae); A postnatal model of forebrain formation
Differential Suppression of Spontaneous and Noxious-evoked Somatosensory Cortical Activity by Isoflurane in the Neonatal Rat
Increasing the interval between repeated anesthetic exposures reduces long-lasting synaptic changes in late post-natal mice.
Closing the gap from transcription to the structural connectome enhances the study of connections in the human brain.
Combining local and global evolutionary trajectories of brain-behavior relationships through game theory- A novel prospective in integrative neuroscience
Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment.
Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain
Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes
Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise
Mathematical Modeling of Cortical Neurogenesis Reveals that the Founder Population does not Necessarily Scale with Neurogenic Output
How Areal Specification Shapes the Local and Interareal Circuits in a Macaque Model of Congenital Blindness
Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone
Synaptic Connectivity and Cortical Maturation Are Promoted by the ω-3 Fatty Acid Docosahexaenoic Acid
Neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
When ontogeny recapitulates phylogeny: Fixed neurodevelopmental sequence of manipulative skills among primates
Respiratory Support of the Preterm Neonate: Lessons About Ventilation-Induced Brain Injury From Large Animal Models
Exposure to ethanol during neurodevelopment modifies crucial offspring rat brain enzyme activities in a region-specific manner
A Review of the New Antiepileptic Drugs for Focal-Onset Seizures in Pediatrics: Role of Extrapolation
Effects of Immune Activation during Early or Late Gestation on N-Methyl-d-Aspartate Receptor Measures in Adult Rat Offspring
LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction
The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice
Effects of neonatal isoflurane anesthesia exposure on learning-specific and sensory systems in adults
Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease
Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome
Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice
Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development
Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity
Gene expression analysis reveals the tipping points during infant brain development for human and chimpanzee
In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques
Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.
Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers
Dose-Dependent Effect of Intravenous Administration of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Neonatal Stroke Mice
Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography
Thalamocortical Afferents Innervate the Cortical Subplate much Earlier in Development in Primate than in Rodent
Spatiotemporal Differences in the Regional Cortical Plate and Subplate Volume Growth during Fetal Development
Understanding the Real State of Human Adult Hippocampal Neurogenesis From Studies of Rodents and Non-human Primates
Maternal Immune Activation Alters Fetal Brain Development and Enhances Proliferation of Neural Precursor Cells in Rats
Sex differences in the nicotinic excitation of principal neurons within the developing hippocampal formation
Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri ) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents
Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model
The developmental support hypothesis: adaptive plasticity in neural development in response to cues of social support
Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine
Comparing Adult Hippocampal Neurogenesis Across Species: Translating Time to Predict the Tempo in Humans
Clusters of DCX+ cells "trapped" in the subcortical white matter of early postnatal Cetartiodactyla (Tursiops truncatus, Stenella coeruloalba and Ovis aries)
Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction.
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective
Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function
Comorbidities of early-onset temporal epilepsy: Cognitive, social, emotional, and morphologic dimensions
Anesthesia affects excitatory/inhibitory synapses during the critical synaptogenic period in the hippocampus of young mice: Importance of sex as a biological variable
General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain.
Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats.
The inflammatory event of birth: How oxytocin signaling may guide the development of the brain and gastrointestinal system
Late post-natal neurometabolic development in healthy male rats using 1 H and 31 P magnetic resonance spectroscopy.
Cutting across structural and transcriptomic scales translates time across the lifespan in humans and chimpanzees.
Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains
Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain-A new treatment strategy for neonatal seizures?
Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Systemic Juvenile Idiopathic Arthritis
Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.
Chromatin Regulation and Circadian Clocks
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Central Pontine Myelinolysis
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Cell Atlas Along the Gut-Brain Axis
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