Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets

PloS One
Samar Hayat Khan Tareen, Jamil Ahmad

Abstract

Circadian rhythms are certain periodic behaviours exhibited by living organism at different levels, including cellular and system-wide scales. Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding. These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock. These entities, along with abstracted feeding induced signals were modelled collectively in this study using Petri Nets. The properties of the model show that the circadian system itself is strongly robust, and is able to continually evolve. The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.

References

Jan 1, 1987·Journal of Mathematical Biology·S H Strogatz
Mar 1, 1969·Journal of Theoretical Biology·S A Kauffman
May 1, 1996·Annals of Surgery·J A EhrenfriedJ C Thompson
Mar 26, 2002·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Hidde de Jong
May 17, 2002·Nature·Satchidananda PandaSteve A Kay
Jul 29, 2004·FEBS Letters·Kensaku KatsukiAkira Nakai
Sep 7, 2004·Biophysical Journal·Sabine Becker-WeimannAchim Kramer
Sep 15, 2004·Journal of Theoretical Biology·Jean-Christophe Leloup, Albert Goldbeter
Jan 3, 2006·Bio Systems·Claudine ChaouiyaDenis Thieffry
Mar 1, 2006·Theoretical Biology & Medical Modelling·Verner PaetkauReinhard Illner
Mar 29, 2006·Journal of Bioinformatics and Computational Biology·Hiroshi MatsunoSatoru Miyano
Jan 30, 2007·Journal of Biomedical Informatics·Dorota FormanowiczJacek Błazewicz
Jul 13, 2007·Briefings in Bioinformatics·Claudine Chaouiya
Aug 9, 2007·PloS One·Frank A J L ScheerCharles A Czeisler
Jul 22, 2008·International Journal of Bioinformatics Research and Applications·Jamil AhmadUNKNOWN Adrien Richard
Oct 1, 2008·Biochemical and Biophysical Research Communications·Zhanguo Gao, Jianping Ye
Mar 21, 2009·Science·Kathryn Moynihan RamseyJoseph Bass
May 28, 2009·Molecular and Cellular Biology·Senthilkumar B RajamohanMahesh P Gupta
Oct 29, 2009·Carcinogenesis·Pamela K Kreeger, Douglas A Lauffenburger
Jul 9, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shirong Wang, Eric E Turner
Oct 1, 1991·Journal of the Royal Society of Medicine·W R Ayers
Oct 15, 2010·Nature Reviews. Molecular Cell Biology·Alison Schuldt
Nov 5, 2010·Journal of Cell Science·Marina Maria Bellet, Paolo Sassone-Corsi
Nov 26, 2010·Nutrition Journal·John F Trepanowski, Richard J Bloomer
Dec 8, 2010·International Journal of Data Mining and Bioinformatics·Jamil Ahmad, Olivier Roux
Feb 3, 2011·Cell Metabolism·Gad Asher, Ueli Schibler
Jun 3, 2011·The Journal of Clinical Investigation·Wenyu HuangJoseph Bass
Aug 16, 2011·Physiology·Oren Froy
Dec 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·M M BelletP Sassone-Corsi
Feb 4, 2012·PloS One·Adrien RichardAnnabelle Merieau
Mar 13, 2012·Cell Metabolism·Darwin JeyarajMukesh K Jain

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Citations

May 5, 2017·Gene Regulation and Systems Biology·Seul-A Bae, Ioannis P Androulakis
Jan 20, 2018·American Journal of Physiology. Endocrinology and Metabolism·Seul-A Bae, Ioannis P Androulakis
Sep 27, 2019·Frontiers in Nutrition·Seul-A BaeIoannis P Androulakis
May 4, 2017·BMC Systems Biology·Olga A PodkolodnayaNikolay L Podkolodnyy
Jun 8, 2018·Frontiers in Neuroinformatics·Javaria AshrafZaheer Ul-Haq

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