Modelling baculovirus infection of insect cells in culture.

Cytotechnology
J F Power, Lars K Nielsen

Abstract

Infection of insect cells with baculovirus is a potentially attractive means for producing both viral insecticides and recombinant proteins. The continuation of mathematical modelling studies such as those reviewed in this paper are essential in order to realise the full potential of the system. Through mathematical models it is possible to predict complex behaviours such as those observed when infecting cells at low MOI or when propagating virus in a continuous culture system. A purely empirical analysis of the same phenomena is very difficult if not impossible.The present three models are - despite their complexity and the effort that has gone into developing them - all first generation models. They summarise, to a large extent, our present quantitative understanding of the interaction between baculovirus and insect cells, when looked upon as a black box system. The binding and initial infection processes are still quantitatively poorly understood and further work in this area is much needed. On the longer term, a second generation of models is likely to consider interior processes such as viral DNA and RNA accumulation in much more detail using a structured model of the infection cycle.

References

Apr 1, 1990·Applied Microbiology and Biotechnology·F L van LierJ Tramper
Dec 1, 1990·Biophysical Journal·T J WickhamM L Shuler
Jan 1, 1990·Annals of the New York Academy of Sciences·M L ShulerH A Wood
Jan 1, 1988·Annual Review of Microbiology·L K Miller
Mar 15, 1992·Biotechnology and Bioengineering·D A Lindsay, M J Betenbaugh
Aug 5, 1992·Biotechnology and Bioengineering·C D De GooijerJ Tramper
Jun 20, 1993·Biotechnology and Bioengineering·S ReuvenyJ Shiloach
Sep 5, 1994·Biotechnology and Bioengineering·J F PowerL K Nielsen

❮ Previous
Next ❯

Citations

Oct 19, 2002·Journal of Biotechnology·P E CruzM J T Carrondo
Jun 11, 2005·Biotechnology and Bioengineering·Richard Haas, Lars K Nielsen
May 9, 2012·Journal of Virological Methods·Leila MatindoostSteven Reid
Sep 24, 2004·Biotechnology and Bioengineering·Y Sidorenko, U Reichl
Jun 28, 2005·Journal of Theoretical Biology·Giora EndenJosé C Merchuk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.