DOI: 10.1101/479881Nov 28, 2018Paper

Modelling conduction delays in the corpus callosum using MRI-measured g-ratio

BioRxiv : the Preprint Server for Biology
Shai BermanA Mezer

Abstract

Conduction of action potentials along myelinated axons is affected by their structural features, such as the axonal g-ratio, the ratio between the inner and outer diameters of the myelin sheath surrounding the axon. The effect of g-ratio variance on conduction properties has been quantitatively evaluated using single-axon models. It has recently become possible to estimate a g-ratio weighted measurement in vivo using quantitative MRI. Nevertheless, it is still unclear whether the variance in the g-ratio in the healthy human brain leads to significant differences in conduction velocity. In this work we tested whether the g-ratio MRI measurement can be used to predict conduction delays in the corpus callosum. We present a novel framework in which the structural properties of fibers (i.e. length and g-ratio, measured using MRI), are incorporated in a biophysical model of axon conduction, to predict conduction delays of long-range white matter fibers. We applied this framework to the corpus callosum, and found conduction delay estimates that are compatible with previously estimated values of conduction delays. We account for the variance in the velocity given the axon diameter distribution in the splenium, mid-body and genu, to fur...Continue Reading

Related Concepts

Axon
Brain
Corpus Callosum
Magnetic Resonance Imaging
Myelin Sheath
Fiber
Latent Virus Infection Process
Structure
White Matter
Entire Mid Right Atrium

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