Modelling energy deposition in nanoscintillators to predict the efficiency of the X-ray-induced photodynamic effect

Nanoscale
Anne-Laure BulinChristophe Dujardin

Abstract

Scintillating nanoparticles (NPs) in combination with X-ray or γ-radiation have a great potential for deep-tissue cancer therapy because they can be used to locally activate photosensitizers and generate singlet oxygen in tumours by means of the photodynamic effect. To understand the complex spatial distribution of energy deposition in a macroscopic volume of water loaded with nanoscintillators, we have developed a GEANT4-based Monte Carlo program. We thus obtain estimates of the maximum expected efficiency of singlet oxygen production for various materials coupled to PS, X-ray energies, NP concentrations and NP sizes. A new parameter, ηnano, is introduced to quantify the fraction of energy that is deposited in the NPs themselves, which is crucial for the efficiency of singlet oxygen production but has not been taken into account adequately so far. We furthermore emphasise the substantial contribution of primary interactions taking place in water, particularly under irradiation with high energy photons. The interplay of all these contributions to the photodynamic effect has to be taken into account in order to optimize nanoscintillators for therapeutic applications.

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Citations

Jul 15, 2016·Optics Express·Hana BurešováVáclav Čuba
Oct 11, 2016·Chemical Society Reviews·Zijian ZhouXiaoyuan Chen
May 8, 2018·Advanced Materials·Tibor Jacob HajagosQibing Pei
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Apr 20, 2018·Radiation Research·Konstantin A KudinovStephen E Bradforth
Aug 1, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Benjamin ClineJin Xie
Dec 14, 2018·Physics in Medicine and Biology·Justin S KleinGuillem Pratx
Feb 6, 2017·Optics Express·M S AlekhinM Stampanoni
Oct 24, 2018·Journal of Biomedical Optics·Brian W Pogue, Brian C Wilson
Apr 13, 2019·Physics in Medicine and Biology·R M TurtosP Lecoq
Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Mar 16, 2021·ACS Applied Materials & Interfaces·Irene VillaAngelo Monguzzi
Feb 13, 2020·Inorganic Chemistry·Liujing XieXiaoning Cheng
Sep 6, 2018·ACS Applied Materials & Interfaces·Mateusz OdziomekStephane Parola

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