Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis

International Journal of Health Geographics
Yordanos B MollaGail Davey

Abstract

The precise trigger of podoconiosis - endemic non-filarial elephantiasis of the lower legs - is unknown. Epidemiological and ecological studies have linked the disease with barefoot exposure to red clay soils of volcanic origin. Histopathology investigations have demonstrated that silicon, aluminium, magnesium and iron are present in the lower limb lymph node macrophages of both patients and non-patients living barefoot on these clays. We studied the spatial variation (variations across an area) in podoconiosis prevalence and the associated environmental factors with a goal to better understanding the pathogenesis of podoconiosis. Fieldwork was conducted from June 2011 to February 2013 in 12 kebeles (administrative units) in northern Ethiopia. Geo-located prevalence data and soil samples were collected and analysed along with secondary geological, topographic, meteorological and elevation data. Soil data were analysed for chemical composition, mineralogy and particle size, and were interpolated to provide spatially continuous information. Exploratory, spatial, univariate and multivariate regression analyses of podoconiosis prevalence were conducted in relation to primary (soil) and secondary (elevation, precipitation, and geolo...Continue Reading

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Citations

Aug 4, 2015·Environment International·Nicola Ann Wardrop, Jennifer Susan Le Blond
Mar 3, 2015·Medicina clínica·Laura Prieto-PérezMiguel Górgolas Hernández-Mora
Jul 30, 2015·PLoS Neglected Tropical Diseases·Kebede DeribeSimon J Brooker
Nov 21, 2017·Wellcome Open Research·Kebede DeribeGail Davey
Jul 3, 2018·PLoS Neglected Tropical Diseases·Biruk KebedeCharles D Mackenzie
Jun 28, 2018·BMJ Global Health·Kebede DeribeSamuel Wanji
Sep 7, 2018·Environmental Geochemistry and Health·Jamey N CooperKevin E Nick
Oct 3, 2018·Tropical Medicine and Infectious Disease·Damilare O Famakinde, Adedotun A Adenusi
Oct 3, 2018·Tropical Medicine and Infectious Disease·Abebayehu ToraMaya Semrau
Dec 4, 2019·PLoS Neglected Tropical Diseases·Kebede DeribeGail Davey
Nov 11, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Kebede DeribeGail Davey
Dec 2, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bertrand Lontum NdzeshangSamuel Wanji
Nov 22, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Maya SemrauKebede Deribe
Nov 21, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·H GislamJ S Le Blond
Apr 12, 2021·Acta Tropica·Samuel WanjiManuel Ritter
Feb 27, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·David J ChandlerLucinda C Fuller

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Methods Mentioned

BETA
PMA

Software Mentioned

geoR
ArcGIS
R

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