Modelling EuroQol health-related utility values for diabetic complications from CODE-2 data

Health Economics
Adrian Bagust, Sophie Beale

Abstract

Recent research has employed different analytical techniques to estimate the impact of the various long-term complications of type 2 diabetes on health-related utility and health status. However, limited patient numbers or lack of variety of patient experience has limited their power to discriminate between separate complications and grades of severity. In this study alternative statistical model forms were compared to investigate the influence of various factors on self-assessed health status and calculated utility scores, including the presence and severity of complications, and type of diabetes therapy. Responses to the EuroQol EQ-5D questionnaire from 4641 patients with type 2 diabetes in 5 European countries were analysed. Simple multiple regression analysis was used to model both visual analogue scale (VAS) scores and time trade-off index scores (TTO). Also, two complex models were developed for TTO analysis using a structure suggested by the EuroQol calculation algorithm. Both VAS and TTO models achieved greater explanatory power than in earlier studies. Relative weightings for individual complications differed between VAS and TTO scales, reflecting the strong influence of loss of mobility and severe pain in the EuroQol ...Continue Reading

References

Jan 12, 1999·Diabetes Research and Clinical Practice·J HänninenS Keinänen-Kiukaanniemi
Feb 24, 2001·Medical Decision Making : an International Journal of the Society for Medical Decision Making·X BadiaP Kind
Nov 14, 2001·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·A LloydP Hopkinson
Jul 24, 2002·Diabetologia·M Massi-Benedetti, UNKNOWN CODE-2 Advisory Board
Jul 24, 2002·Diabetologia·M Koopmanschap, UNKNOWN CODE-2 Advisory Board
Aug 2, 2002·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Philip ClarkeRury Holman
Jul 1, 2002·Diabetologia·M Koopmanschap

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Citations

May 29, 2009·Inflammatory Bowel Diseases·Renee G StarkHans-Helmut König
Jul 30, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Ulf PerssonKnut Odegaard
Jul 20, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Louis S MatzaBeth L Barber
Oct 31, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·David H SmithJonathan Betz-Brown
Jan 12, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Daria J O'ReillyRon A Goeree
Apr 8, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Tom W C LungPhilip M Clarke
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruce R SchackmanKenneth A Freedberg
Jan 2, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melissa A BenderKenneth A Freedberg
May 9, 2014·International Journal of Environmental Research and Public Health·Aliasghar A KiadaliriKatarina Steen Carlsson
Nov 23, 2013·Science·Kenneth R KoedingerDavid Klahr
Jun 21, 2014·Journal of Medical Economics·Katarina Steen Carlsson, Ulf Persson
May 9, 2012·Journal of Medical Economics·J Smith-PalmerW J Valentine
Sep 14, 2010·International Journal of Audiology·Dafydd StephensYrjö Auramo
Jan 4, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·Victoria K BrennanRoberto Palencia
Jul 27, 2007·Current Medical Research and Opinion·Louis S MatzaJodi M Shorr
Jul 21, 2010·Current Medical Research and Opinion·Y YiK Burslem
Oct 22, 2005·Current Medical Research and Opinion·Joshua A RayAndrew J Palmer
Jun 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·W J ValentineUNKNOWN PROactive Study Group
Jan 23, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Alison HayesPhilip Clarke
Dec 14, 2011·European Journal of Internal Medicine·Yong YangHan Seong Ng
Dec 7, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Julia M Bottomley, Frank D Raymond
Sep 19, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·C Ll MorganC J Currie
Mar 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·M F JanssenA S Pickard

❮ Previous
Next ❯

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