Modelling hyaluronan degradation by streptococcus pneumoniae hyaluronate lyase

Mathematical Biosciences
Vinh Q MaiMartin Meere

Abstract

Hyaluronic acid (Hyaluronan) is a linear, high molecular weight polysaccharide that forms an important component of the extracellular matrix. It is an excellent biomaterial, and it is increasingly being used in biotechnology, biomedical applications, and drug delivery. Polymer chains of hyaluronan occur in many different lengths in nature, and can be as large as multiples of ten thousand. Since the biological function of a hyaluronan chain often depends on its molecular weight, it is of value for applications to develop reliable quantitative descriptions of the degradation processes of hyaluronan. In particular, the development of such models should assist with the rational design of production processes to create polymer chains in a given molecular weight category for a specific application. In this paper, we propose a new mathematical model for the degradation of hyaluronan by the enzyme streptococcus pneumoniae hyaluronate lyase. The model is based on a processive kinetic mechanism and consists of a coupled system of nonlinear ordinary differential equations for the species of interest. The model parameters are estimated using published experimental data, and good agreement between theory and experiment is found. Numerical e...Continue Reading

Citations

Oct 11, 2020·International Journal of Biological Macromolecules·Yujiao LiFeng Han
Oct 15, 2020·Carbohydrate Polymers·Matěj ŠimekVladimír Havlíček

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