Modelling methodology in physiopathology

Progress in Biophysics and Molecular Biology
Jean-Pierre BoisselMarie-Aimée Dronne

Abstract

Diseases are complex systems. Modelling them, i.e. systems physiopathology, is a quite demanding, complicated, multidimensional, multiscale process. As such, in order to achieve the goal of the model and further to optimise a rather-time and resource-consuming process, a relevant and easy to practice methodology is required. It includes guidance for validation. Also, the model development should be managed as a complicated process, along a strategy which has been elaborated in the beginning. It should be flexible enough to meet every case. A model is a representation of the available knowledge. All available knowledge does not have the same level of evidence and, further, there is a large variability of the values of all parameters (e.g. affinity constant or ionic current) across the literature. In addition, in a complex biological system there are always values lacking for a few or sometimes many parameters. All these three aspects are sources of uncertainty on the range of validity of the models and raise unsolved problems for designing a relevant model. Tools and techniques for integrating the parameter range of experimental values, level of evidence and missing data are needed.

References

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Dec 14, 2007·Progress in Biophysics and Molecular Biology·Marie-Aimée DronneJean-Pierre Boissel
Jan 22, 2008·Progress in Biophysics and Molecular Biology·E GrenierJ-P Boissel

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Citations

Apr 8, 2009·Genome Medicine·Charles AuffrayLeroy Hood
Jan 15, 2013·Mathematical Biosciences and Engineering : MBE·Floriane LignetBenjamin Ribba
Jan 1, 2014·Orphanet Journal of Rare Diseases·Patrice NonyUNKNOWN Epi-CRESim
Jul 19, 2015·Journal of Clinical Epidemiology·Agathe BajardUNKNOWN CRESim & Epi-CRESim study groups
Aug 1, 2015·CPT: Pharmacometrics & Systems Pharmacology·J-P BoisselF-H Boissel
May 19, 2011·Nature Reviews. Neuroscience·Arjen van Ooyen
Dec 25, 2019·Physical Review. E·Donald J DeGraciaZhi-Feng Huang
Mar 12, 2020·Thérapie·Patrice NonyUNKNOWN CRESim, Epi-CRESim research groups

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