Modelling NAFLD disease burden in four Asian regions-2019-2030.

Alimentary Pharmacology & Therapeutics
Chris EstesHomie Razavi

Abstract

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) account for an increasing proportion of liver disease in the Asia-Pacific region. Many areas in the region are experiencing epidemics of metabolic syndrome among rapidly ageing populations. To estimate using modelling the growth in NAFLD populations, including cases with significant fibrosis that are most likely to experience advanced liver disease and related mortality. A disease progression model was used to summarise and project fibrosis progression among the NAFLD populations of Hong Kong, Singapore, South Korea and Taiwan. For each area, changes in the adult prevalence of obesity was used to extrapolate long-term trends in NAFLD incidence. In the areas studied, prevalent NAFLD cases were projected to increase 6%-20% during 2019-2030, while prevalent NASH cases increase 20%-35%. Incident cases of hepatocellular carcinoma are projected to increase by 65%-85%, while incident decompensated cirrhosis cases increase 65%-100% by 2030. Likewise, NAFLD-related mortality is projected to increase between 65% and 100% from 2019 to 2030. NAFLD disease burden is expected to increase alongside rising trends in metabolic syndrome and obesity among populatio...Continue Reading

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Citations

May 24, 2020·Alimentary Pharmacology & Therapeutics·Kee-Huat Chuah, Wah-Kheong Chan
May 24, 2020·Alimentary Pharmacology & Therapeutics·Chris EstesHomie Razavi
Feb 3, 2021·Clinical Therapeutics·Wei-Kei Wong, Wah-Kheong Chan
Mar 19, 2021·Journal of Gastroenterology and Hepatology·Chee-Kiat TanShikha Singh
Apr 25, 2021·Lancet·Elizabeth E PowellMary Rinella
Jun 10, 2021·Journal of Gastroenterology and Hepatology·Terry Cheuk-Fung YipGrace Lai-Hung Wong
Aug 12, 2021·Alimentary Pharmacology & Therapeutics·Kenneth I Zheng, Ming-Hua Zheng
Aug 11, 2021·Journal of Digestive Diseases·Shu Jing XiaJian Gao Fan

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BETA
biopsy

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Crystal Ball®
Excel

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