Modelling neurodegenerative disease using brain organoids.

Seminars in Cell & Developmental Biology
Selina Wray

Abstract

Neurodegenerative Diseases such as Alzheimer's Disease represent a major public health challenge, with no disease modifying therapies available. The availability of induced pluripotent stem cells from patients with phenotypes and genotypes of interest, that can be subsequently differentiated in vitro into disease-affected cell types, has revolutionised our ability to generate physiologically relevant disease models. The recent availability of brain organoids - self-organising in vitro tissue models - as enabled the generation of complex, multicellular systems to study brain development and disease. Although widely used for modelling neurodevelopment, early studies have demonstrated great promise in the use of organoids as models of neurodegenerative disease. Here, I will review recent progress to model neurodegenerative diseases using organoids and comment on future directions and challenges.

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Gianluca CostamagnaStefania Corti
Mar 27, 2021·International Journal of Biological Macromolecules·Cameron WellsLezanne Ooi
Aug 21, 2021·Cell·Laura Pellegrini, Madeline A Lancaster
Aug 28, 2021·Cells·Nelly RedolfiDiana Pendin
Sep 2, 2021·Annual Review of Biomedical Data Science·Jonathan Li, Ernest Fraenkel

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3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

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