Modelling of chromatin morphologies in breast cancer cells undergoing apoptosis using generalized Cauchy field

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society
S V Muniandy, J Stanslas

Abstract

Chromatin morphologies in human breast cancer cells treated with an anti-cancer agent are analyzed at their early stage of programmed cell death or apoptosis. The gray-level images of nuclear chromatin are modelled as random fields. We used two-dimensional isotropic generalized Cauchy field to characterize local self-similarity and global long-range dependence behaviors in the image spatial data. Generalized Cauchy field allows the description of fractal behavior inferred from fractal dimension and the long-range dependence inferred from correlation exponent to be carried out independently. We demonstrated the usefulness of locally self-similar random fields with long-range dependence for modelling chromatin condensation.

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Citations

Sep 26, 2013·Expert Review of Molecular Diagnostics·Konradin Metze
Mar 12, 2015·Journal of Tissue Engineering and Regenerative Medicine·Joana LoboAbhay Pandit
May 25, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Katarzyna MitręgaTadeusz F Krzemiński
Jul 6, 2012·Journal of Theoretical Biology·Igor PanticVladimir Trajkovic
Feb 28, 2015·Ontogenez·V N IakimovD B Gelashvili

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