Modelling of multiple sclerosis: lessons learned in a non-human primate

Lancet Neurology
Bert A 't HartRogier Q Hintzen

Abstract

The many, highly specific, biological therapies for immune-based diseases create a need for valid preclinical animal models. The wide immunological gap between human beings and laboratory mouse or rat models makes many disease models in these species invalid. In this review, we report a non-human-primate model of chronic multiple sclerosis (MS)-experimental autoimmune encephalitis (EAE) in the common marmoset (Callithrix jacchus)-that can help bridge this wide gap. The genetic and immunological similarity of marmosets and human beings and the clinical and neuropathological similarity of the EAE model to MS provide a unique experimental platform for research into basic immunopathogenetic mechanisms and for the development of more effective treatments for MS.

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Citations

Oct 15, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yolanda S KapBert A 't Hart
Feb 16, 2006·Drug Discovery Today·Bert A 't HartErwin L A Blezer
Oct 17, 2009·Journal of Human Genetics·Ilse A HoppenbrouwersRogier Q Hintzen
Aug 26, 2006·Nature Clinical Practice. Neurology·Reinhard Hohlfeld, Hartmut Wekerle
Apr 2, 2013·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Shoji TatsumotoMasanobu Satake
May 17, 2012·Therapeutic Advances in Neurological Disorders·Marie Cathrin Mayer, Edgar Meinl
Jul 1, 2005·Arthritis Research & Therapy·Michel P M VierboomBert 't Hart
Oct 28, 2010·Arthritis Research & Therapy·Michel P M VierboomBert A 't Hart
Aug 12, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yolanda S KapBert A 't Hart
Oct 6, 2009·Seminars in Immunopathology·Bettina SchreinerBurkhard Becher
Feb 9, 2016·International Journal of Experimental Pathology·Michelle NelsonTimothy P Atkins
Apr 2, 2009·Journal of Neuropathology and Experimental Neurology·Bert A 't Hart, Luca Massacesi
Oct 18, 2011·Journal of Neuropathology and Experimental Neurology·Yolanda S KapBert A 't Hart
May 16, 2015·International Immunology·Shin ShimadaYoshie Kametani
Mar 18, 2005·Journal of Neuroscience Research·A IwanamiH Okano
Oct 3, 2009·Annals of Neurology·Stefano PluchinoGianvito Martino
Dec 17, 2008·Veterinary Ophthalmology·Cornelia A Deeg
Mar 23, 2011·European Journal of Clinical Investigation·Adam E HandelSreeram V Ramagopalan
Nov 30, 2011·International Journal of Experimental Pathology·Michelle NelsonMark S Lever
Jul 19, 2005·Journal of Neuroimmunology·Bert A 't HartSandra Amor
Jul 25, 2015·Brain Pathology·Ruth Martha StassartWolfgang Brück
Jul 18, 2009·Biochimica Et Biophysica Acta·Peizhong Mao, P Hemachandra Reddy
Nov 26, 2008·Veterinary Immunology and Immunopathology·Cornelia A Deeg
Oct 12, 2010·Biochimica Et Biophysica Acta·Ilse A Hoppenbrouwers, Rogier Q Hintzen
Apr 30, 2016·Nature Reviews. Neurology·Martina AbsintaDaniel S Reich
Oct 3, 2006·Current Opinion in Immunology·Kristine KiklyJonathon D Sedgwick
May 10, 2007·Nature Protocols·Ingunn M Stromnes, Joan M Goverman
Mar 11, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Emma C TallantyreNikos Evangelou
Feb 22, 2018·Expert Opinion on Drug Discovery·Bert A 't HartYolanda S Kap
Sep 10, 2005·Brain : a Journal of Neurology·Ian M PomeroyMargaret M Esiri
Apr 27, 2011·Current Opinion in Neurology·Andrew R Pachner
Aug 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yolanda S KapBert A 't Hart

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