Modelling of silk-reinforced PDMS properties for soft tissue engineering applications

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
Artūras KilikevičiusRimantas Kačianauskas

Abstract

Polydimethylsiloxane (PDMS) is widely used in biomedical research and technology, but its mechanical properties should be tuned according to the desired product specifications. Mixing ratio of base polymer to curing agent or additives enables its mechanical properties to be manipulated and fit to mechanical properties of biological tissues. In this paper, we analysed the effect of mechanical load on silk-reinforced PDMS depending on silk concentration. We prepared cylinder-type PDMS samples with different silk concentrations and performed cyclic uniaxial compression tests with a fixed magnitude of applied strain. Next, we analysed the mechanical charascteristics of PDMS using computational modelling. The stress-strain data within the large-strain region of different PDMS cylinders without silk and with 1%, 5% and 10% silk concentrations was fitted to non-linear second order Mooney-Rivlin, and third-order Ogden models. The results show the equivalence of both models for investigated strain region of PDMS. On the other hand, PDMS cylinders with 10% silk concentration allowed the successful fitting of experimental data just for the second-order Mooney-Rivlin model, while all numerical probes to find an appropriate fitting paramete...Continue Reading

References

Dec 2, 2004·Cell Motility and the Cytoskeleton·Tony YeungPaul A Janmey
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olivia du RoureBenoit Ladoux
Nov 16, 2005·Lab on a Chip·Aigars PiruskaCarl J Seliskar
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Dec 4, 2008·Journal of Tissue Engineering and Regenerative Medicine·E HadjipanayiR A Brown
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Amy L Paguirigan, David J Beebe
Oct 1, 2011·Nature Protocols·Danielle N RockwoodDavid L Kaplan
Sep 12, 2015·Acta Biomaterialia·Johanna MelkeSandra Hofmann
Sep 25, 2017·Acta Biomaterialia·Promita BhattacharjeeSubhas C Kundu
Feb 12, 2018·ACS Biomaterials Science & Engineering·Veli OzbolatIbrahim T Ozbolat

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