Modelling of the blood-brain barrier

Médecine sciences : M/S
Fabien Gosselet

Abstract

The blood-brain barrier (BBB) is located at the brain microvessel level and isolates the brain from the whole body, thus restricting molecule and cell exchanges between cerebral and peripheral compartments. In order to better decipher and understand the BBB physiology and development, and to investigate transport mechanism and toxicity of neuropharmaceuticals, several in vitro BBB models have been developed using animal or human cells, primary or immortalized cells. The aim of this review is to explain to the reader the major criteria required for a pertinent in vitro BBB model and to briefly expose the different models currently available with their characteristics with a special focus on the static models.

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Citations

Apr 17, 2018·Médecine sciences : M/S·Julien Saint-Pol, Fabien Gosselet
Apr 26, 2018·Frontiers in Endocrinology·Dorothée DomengerRozenn Ravallec
Aug 16, 2019·Cellular and Molecular Neurobiology·Takashi FujimotoTakayuki Matsuo
Jul 6, 2021·Pharmaceutical Development and Technology·Rosamaria LombardoRosario Pignatello

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