Modelling of tumour repopulation after chemotherapy

Australasian Physical & Engineering Sciences in Medicine
Loredana Marcu, Eva Bezak

Abstract

While repopulation is a clinically observed phenomenon after radiotherapy, repopulation of tumour cells between cycles of chemotherapy is usually a neglected factor in cancer treatment. As the effect of both radiotherapy and chemotherapy on tumour cells is the same (attack on cancer cells), the response of the tumour to injury and cell loss from the two treatment methods should be similar, including repopulation. Cell recruitment is known to be a possible mechanism responsible for tumour regrowth after radiotherapy. The literature data regarding mechanisms of repopulation after chemotherapy is very limited. The current paper employs a Monte Carlo modelling approach to implement the pharmacokinetics of a widely used drug (cisplatin) into a previously developed virtual head and neck tumour and to study the effect of cisplatin on tumour regression and regrowth during treatment. The mechanism of cell recruitment was modelled by releasing various percentages (5-50%) of quiescent cells into the mitotic cycle after each chemotherapy cell kill. The onset of repopulation was also simulated, with both immediate onset and late onset of cell recruitment. Repopulation during chemotherapy, if occurring, is a highly potent phenomenon, similar...Continue Reading

References

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Mar 22, 2002·The Lancet Oncology·A J Davis, J F Tannock
Jul 16, 2003·Australasian Physical & Engineering Sciences in Medicine·L MarcuI Olver
Sep 28, 2004·Physics in Medicine and Biology·L MarcuI Olver
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Jian Z Wang, X Allen Li
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangRobert D Stewart
Dec 3, 2008·Physics in Medicine and Biology·Adrienne CampbellEugene Wong

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Citations

Aug 2, 2012·Computational and Mathematical Methods in Medicine·Loredana G Marcu, Wendy M Harriss-Phillips
Sep 10, 2013·Seminars in Radiation Oncology·Mary A ZimmermanChuan-Yuan Li
Dec 21, 2011·Journal of Theoretical Biology·Loredana G Marcu, Eva Bezak

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