Modelling pulmonary blood flow.

Respiratory Physiology & Neurobiology
M H Tawhai, K S Burrowes

Abstract

Computational model analysis has been used widely to understand and interpret complexity of interactions in the pulmonary system. Pulmonary blood transport is a multi-scale phenomenon that involves scale-dependent structure and function, therefore requiring different model assumptions for the microcirculation and the arterial or venous flows. The blood transport systems interact with the surrounding lung tissue, and are dependent on hydrostatic pressure gradients, control of vasoconstriction, and the topology and material composition of the vascular trees. This review focuses on computational models that have been developed to study the different mechanisms contributing to regional perfusion of the lung. Different models for the microcirculation and the pulmonary arteries are considered, including fractal approaches and anatomically-based methods. The studies that are reviewed illustrate the different complementary approaches that can be used to address the same physiological question of flow heterogeneity.

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Citations

Jun 4, 2010·European Journal of Nuclear Medicine and Molecular Imaging·George Laking, Pat Price
Jul 27, 2010·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Ghassan Hamarneh, Preet Jassi
Apr 19, 2011·Progress in Pediatric Cardiology·Kendall S HunterRobin Shandas
Jan 1, 2011·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Reema Mallick, Todd Demmy
Jan 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·J YangR M Henkelman
Feb 14, 2019·Physiological Reviews·Pei Xiong Liew, Paul Kubes
Nov 30, 2019·Nature Reviews. Cancer·Gautier FollainJacky G Goetz
Jun 20, 2020·Journal of Applied Physiology·Peter J NiedbalskiZackary I Cleveland

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