Modelling radiation-induced cell death and tumour re-oxygenation: local versus global and instant versus delayed cell death

Physics in Medicine and Biology
Araceli Gago-AriasJuan Pardo-Montero

Abstract

The resistance of hypoxic cells to radiation, due to the oxygen dependence of radiosensitivity, is well known and must be taken into account to accurately calculate the radiation induced cell death. A proper modelling of the response of tumours to radiation requires deriving the distribution of oxygen at a microscopic scale. This usually involves solving the reaction-diffusion equation in tumour voxels using a vascularization distribution model. Moreover, re-oxygenation arises during the course of radiotherapy, one reason being the increase of available oxygen caused by cell killing, which can turn hypoxic tumours into oxic. In this work we study the effect of cell death kinetics in tumour oxygenation modelling, analysing how it affects the timing of re-oxygenation, surviving fraction and tumour control. Two models of cell death are compared, an instantaneous cell killing, mimicking early apoptosis, and a delayed cell death scenario in which cells can die shortly after being damaged, as well as long after irradiation. For each of these scenarios, the decrease in oxygen consumption due to cell death can be computed globally (macroscopic voxel average) or locally (microscopic). A re-oxygenation model already used in the literatur...Continue Reading

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Citations

May 26, 2017·The British Journal of Radiology·David Robert GrimesSamantha Warren
Oct 24, 2019·Cancer Research·Pedro Rodríguez-BarbeitoJuan Pardo-Montero

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