Modelling Radiation-Induced Salivary Dysfunction during IMRT and Chemotherapy for Nasopharyngeal Cancer Patients.

Cancers
Anna CavalloEster Orlandi

Abstract

Radiation-induced xerostomia is one of the most prevalent adverse effects of head and neck cancer treatment, and it could seriously affect patients' qualities of life. It results primarily from damage to the salivary glands, but its onset and severity may also be influenced by other patient-, tumour-, and treatment-related factors. We aimed to build and validate a predictive model for acute salivary dysfunction (aSD) for locally advanced nasopharyngeal carcinoma (NPC) patients by combining clinical and dosimetric factors. A cohort of consecutive NPC patients treated curatively with IMRT and chemotherapy at 70 Gy (2-2.12 Gy/fraction) were utilised. Parotid glands (cPG, considered as a single organ) and the oral cavity (OC) were selected as organs-at-risk. The aSD was assessed at baseline and weekly during RT, grade ≥ 2 aSD chosen as the endpoint. Dose-volume histograms were reduced to the Equivalent Uniform Dose (EUD). Dosimetric and clinical/treatment features selected via LASSO were inserted into a multivariable logistic model. Model validation was performed on two cohorts of patients with prospective aSD, and scored using the same schedule/scale: a cohort (NPC_V) of NPC patients (as in model training), and a cohort of mixed n...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·G J KutcherR Mohan
Jul 1, 1997·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·H J GuchelaarJ H Meerwaldt
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·A EisbruchJ A Ship
Nov 1, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anke Petra JellemaJohannes A Langendijk
Sep 29, 2009·Journal of Dental Research·O GrundmannK H Limesand
Oct 27, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tara A van de WaterJohannes A Langendijk
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Joseph O DeasyAvraham Eisbruch
Jun 3, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ivo BeetzJohannes A Langendijk
Jul 12, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tiziana RancatiRiccardo Valdagni
Mar 27, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Florian BuettnerChristopher M Nutting
Apr 21, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ivo BeetzJohannes A Langendijk
Aug 3, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tejpal GuptaAnil D'Cruz
Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ivo BeetzJohannes A Langendijk
Mar 21, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hans Paul van der LaanJohannes A Langendijk
Aug 22, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter G HawkinsAvraham Eisbruch
Sep 28, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lisanne V van DijkRoel J H M Steenbakkers
Jun 13, 2018·International Journal of Radiation Oncology, Biology, Physics·Hui WuX Allen Li
Jul 1, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lisanne V van DijkNanna M Sijtsema
Jul 5, 2018·International Journal of Radiation Oncology, Biology, Physics·Alessandro CicchettiRiccardo Valdagni
Jul 14, 2018·International Journal of Radiation Oncology, Biology, Physics·Benjamin S RosenIssam El Naqa
Sep 8, 2018·International Journal of Radiation Oncology, Biology, Physics·Lachlan J McDowellJolie Ringash
Mar 11, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marjan SharabianiCoen Hurkmans
Sep 15, 2020·Frontiers in Oncology·Eva OnjukkaIngmar Lax

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.