Modelling slow wave activity in the small intestine

Journal of Theoretical Biology
A S LinA J Pullan

Abstract

We have developed an anatomically based model to simulate slow wave activity in the small intestine. Geometric data for the human small intestine were obtained from the Visible Human project. These data were used to create a one-dimensional finite element mesh of the entire small intestine using an iterative fitting procedure. The electrically active components of the intestinal walls were modelled using a modified Fitzhugh-Nagumo cell model embedded within a longitudinal smooth muscle layer and a layer containing Interstitial Cells of Cajal. Within these layers, the monodomain equation was used to describe slow wave propagation. To solve the monodomain equation, a high-resolution finite difference grid, with an average spatial resolution of 0.95 mm, was embedded within each finite element. The resulting simulations of intestinal activity agree with the experimental observation that slow wave frequency gradually declines from 12 cycles per minute (cpm) in the duodenum to 8 cpm at the terminal ileum. Furthermore, the simulations demonstrated a decrease in conduction velocity with distance along the small intestine (10.7 cm/s in the duodenum, 5.1cm/s in the jejunum and 1.4 cm/s in the ileum), matching experimental recordings from...Continue Reading

References

Sep 1, 1978·The American Journal of Digestive Diseases·P Fleckenstein
Jan 1, 1969·The American Journal of Digestive Diseases·E J McCoy, R D Baker
Jun 1, 1995·Annals of Surgery·W O RichardsJ P Wikswo
Mar 1, 1996·Journal of the American Medical Informatics Association : JAMIA·V SpitzerD Whitlock
Aug 4, 1999·IEEE Transactions on Bio-medical Engineering·L A BradshawW O Richards
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M SandersS M Ward
Apr 25, 2000·Journal of Theoretical Biology·R R AlievJ P Wikswo
May 22, 2003·Annals of Biomedical Engineering·Martin BuistAndrew Pullan
Jul 5, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wim J E P LammersBetty Stephen
Jan 27, 1956·The Journal of Physiology·H I ARMSTRONGA W SMITH
Feb 6, 2004·Journal of Cardiovascular Electrophysiology·Michael R Franz
May 15, 2004·Progress in Biophysics and Molecular Biology·Andrew PullanMartin Buist
Jan 5, 2006·Canadian Journal of Physiology and Pharmacology·Wim J E P LammersBetty Stephen

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Citations

Jun 27, 2006·Annals of Biomedical Engineering·A S LinA J Pullan
May 4, 2010·Annals of Biomedical Engineering·Martin L BuistYong Cheng Poh
Jul 3, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Donghua LiaoHans Gregersen
Dec 8, 2010·Critical Reviews in Biomedical Engineering·Peng DuAndrew J Pullan
Jan 10, 2009·World Journal of Gastroenterology : WJG·Dong-Hua LiaoHans Gregersen
Nov 13, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Peng DuGregory O'Grady
Dec 25, 2007·Experimental Physiology·Wim J E P Lammers, Betty Stephen
Jul 27, 2010·Biophysical Journal·Martin L Buist, Yong Cheng Poh
Aug 18, 2017·Journal of Neural Engineering·Bradley B BarthXiling Shen
Feb 12, 2010·Physical Biology·A GizziS Filippi
May 17, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·A AltomareS Filippi
Jan 20, 2017·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Pinaki Bhattacharya, Marco Viceconti
Dec 17, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean P Parsons, Jan D Huizinga
Feb 16, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alberto Corrias, Martin L Buist
Aug 21, 2021·Clinical Biomechanics·Aroj BhattaraiThanh Ngoc Tran

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