Modelling structures in cryo-EM maps

Current Opinion in Structural Biology
Sony MalhotraMaya Topf

Abstract

Recent advances in structure determination of sub-cellular structures using cryo-electron microscopy and tomography have enabled us to understand their architecture in a more detailed manner and gain insight into their function. The choice of approach to use for atomic model building, fitting, refinement and validation in the 3D map resulting from these experiments depends primarily on the resolution of the map and the prior information on the corresponding model. Here, we survey some of such methods and approaches and highlight their uses in specific recent examples.

Citations

Oct 8, 2019·Acta Crystallographica. Section D, Structural Biology·Bruno P Klaholz
Dec 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eman Alnabati, Daisuke Kihara
Jul 8, 2020·Annual Review of Virology·Emmanuelle R J QueminKay Grünewald
Mar 1, 2020·Current Opinion in Structural Biology·Benjamin R JaggerAdrian J Mulholland
Sep 1, 2020·Progress in Biophysics and Molecular Biology·Yan ZhangIvet Bahar
Jun 9, 2021·Nature Communications·Sony MalhotraMaya Topf
May 23, 2021·Briefings in Bioinformatics·Luciano A Abriata, Matteo Dal Peraro
Jun 3, 2021·International Journal of Molecular Sciences·Subash C PakhrinDukka B Kc
Jun 19, 2021·Journal of Chemical Information and Modeling·Takaharu MoriYuji Sugita
Jul 6, 2021·Journal of Molecular Biology·Gal MasratiJan Kosinski
Feb 25, 2020·Journal of Chemical Information and Modeling·James S FraserMassimiliano Bonomi
Aug 24, 2021·Frontiers in Molecular Biosciences·Bhaskar DasguptaFlorence Tama
May 19, 2020·Journal of Chemical Information and Modeling·Doo Nam KimKarissa Y Sanbonmatsu
Mar 17, 2020·Journal of Chemical Information and Modeling·Carlos F RodríguezOscar Llorca
Aug 28, 2021·Proteins·Andriy KryshtafovychUNKNOWN AlphaFold2 team

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