Modelling the anabolic response of bone using a cell population model

Journal of Theoretical Biology
Pascal R BuenzliDavid W Smith

Abstract

To maintain bone mass during bone remodelling, coupling is required between bone resorption and bone formation. This coordination is achieved by a network of autocrine and paracrine signalling molecules between cells of the osteoclastic lineage and cells of the osteoblastic lineage. Mathematical modelling of signalling between cells of both lineages can assist in the interpretation of experimental data, clarify signalling interactions and help develop a deeper understanding of complex bone diseases. Several mathematical models of bone cell interactions have been developed, some including RANK-RANKL-OPG signalling between cells and systemic parathyroid hormone PTH. However, to our knowledge these models do not currently include key aspects of some more recent biological evidence for anabolic responses. In this paper, we further develop a mathematical model of bone cell interactions by Pivonka et al. (2008) to include the proliferation of precursor osteoblasts into the model. This inclusion is important to be able to account for Wnt signalling, believed to play an important role in the anabolic responses of bone. We show that an increased rate of differentiation to precursor cells or an increased rate of proliferation of precurso...Continue Reading

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Citations

May 30, 2013·PloS One·Jason M GrahamJames A Martin
May 2, 2013·Biomechanics and Modeling in Mechanobiology·Pascal R BuenzliDavid W Smith
May 31, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·A MoreiraC Geary
Dec 29, 2015·In Silico Cell and Tissue Science·Aurélie CarlierLiesbet Geris
Jul 3, 2013·International Journal for Numerical Methods in Biomedical Engineering·Pascal R BuenzliPeter Pivonka
Jul 1, 2015·Journal of Pharmacokinetics and Pharmacodynamics·Jenny ZhengJuan Jose Perez Ruixo
Feb 25, 2015·Bone·Pascal R Buenzli, Natalie A Sims
Sep 11, 2013·Journal of Biomechanics·Romane BlanchardChristian Hellmich
Jul 6, 2016·Frontiers in Endocrinology·Carole J Proctor, Alison Gartland
Jan 22, 2017·Journal of Theoretical Biology·Marc D Ryser, Kevin A Murgas
Mar 6, 2019·International Journal for Numerical Methods in Biomedical Engineering·Madalena M A PeyroteoRenato M Natal Jorge
May 31, 2018·Biomechanics and Modeling in Mechanobiology·Mohd Almie Alias, Pascal R Buenzli
Apr 23, 2019·Journal of Theoretical Biology·Silvia TrichiloPeter Pivonka

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