Modelling the bronchial epithelium in chronic obstructive pulmonary disease using human induced pluripotential stem cells

Revue des maladies respiratoires
M FieldèsJ De Vos

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease leading to irreversible destruction of the terminal bronchioles. Although the precise patho-physiological mechanisms remain to be elucidated, the bronchial epithelium seems to play a pivotal role in the disease. Recent studies have highlighted a great heterogeneity among COPD patients, with various disease courses including, in about half the cases, an origin in childhood. Modelling of COPD is a major goal but currently available models are imperfect. Our work aims to create a new in vitro cellular model to study the pathology of the disease. The differentiation of human induced pluripotential stem cells (hiPSCs) in bronchial epithelium is a step towards a better understanding of the developmental origin and the identification of new therapeutic targets.

References

Oct 27, 2006·Proceedings of the American Thoracic Society·Scott H Randell
Apr 7, 2007·American Journal of Respiratory Cell and Molecular Biology·Andrea J RossRobert B Devlin
Sep 4, 2007·Lancet·David M Mannino, A Sonia Buist
Sep 1, 2009·Lancet·Sundeep S Salvi, Peter J Barnes
Oct 20, 2009·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Noemi FusakiMamoru Hasegawa
Oct 28, 2011·The New England Journal of Medicine·John E McDonoughJames C Hogg
Jul 19, 2014·Science·Madeline A Lancaster, Juergen A Knoblich
Sep 1, 2016·The New England Journal of Medicine·Fernando D Martinez
Apr 25, 2017·Nature Cell Biology·Ya-Wen ChenHans-Willem Snoeck
Apr 26, 2017·American Journal of Respiratory Cell and Molecular Biology·Josiah E RadderSteven D Shapiro
May 5, 2017·BMC Pulmonary Medicine·Delphine GrasIsabelle Vachier
May 5, 2017·Tobacco Induced Diseases·Vahideh GhoraniMajid Kianmeher
May 18, 2017·Lancet·Klaus F Rabe, Henrik Watz
May 19, 2018·The European Respiratory Journal·Philippe BonniaudMartin Kolb
Jan 22, 2019·Nature Protocols·Alyssa J MillerJason R Spence
Feb 16, 2019·The Lancet. Respiratory Medicine·Alvar Agusti, Rosa Faner
May 16, 2019·The New England Journal of Medicine·Richard C Boucher
Sep 26, 2019·The New England Journal of Medicine·Alvar Agustí, James C Hogg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
James C Hogg
British Journal of Experimental Pathology
R B Taylor
© 2021 Meta ULC. All rights reserved