PMID: 9440305Jan 24, 1998Paper

Modelling the control of ovulation and polycystic ovary syndrome

Journal of Mathematical Biology
A Chávez-RossJ Stark

Abstract

The control of ovulation in mammalian species appears to be a highly robust process. The primary mechanism is believed to be competition amongst a group of developing follicles, mediated by a hormonal feedback loop involving in the first instance the pituitary. Successful follicles reach maturity and ovulate, the remainder atrophy and die. A model of this control process has been derived by Lacker and his group. Based on simple qualitative assumptions about the hormonal feedback loop, this is able to reflect many of the basic physiological features of ovulation in mammals. However, a fundamental hypothesis of Lacker's work is that all follicles are identical and respond to hormonal signals in precisely the same way. Not only is this improbable, but it also leads to several aspects of the model which are qualitatively unrealistic, most notable of these is its inability to accurately model the condition known as Polycystic Ovary Syndrome. This common malfunction of the ovulatory control mechanism accounts for up to three-quarters of cases of anovulatory infertility in humans and its understanding is therefore of considerable medical significance. In this paper we extend the analysis of Lacker's model to the case of non-identical ...Continue Reading

Citations

Aug 30, 2000·Molecular and Cellular Endocrinology·S FranksD Willis
Jul 16, 2014·Nature Reviews. Endocrinology·Channa N Jayasena, Stephen Franks
Sep 12, 2002·Journal of the American Medical Informatics Association : JAMIA·Dimitra Tsavachidou, Michael N Liebman
Mar 17, 2001·Evolution & Development·C J ZhengB Byers
Nov 1, 2011·Fertility and Sterility·Renato FanchinJean-Marc Ayoubi
Apr 24, 2007·Journal of Theoretical Biology·Isabel Reinecke, Peter Deuflhard
Oct 22, 2010·Journal of Neuroendocrinology·D LylesM L Zeeman
Sep 28, 2005·Mathematical Biosciences·Gordon E Sarty, Roger A Pierson
Jul 26, 2005·Mathematical Biosciences·Nki EchenimFrédérique Clément
Aug 29, 2012·Journal of Theoretical Biology·Stephen R PringPhilip C Garnsworthy
Dec 18, 2001·Journal of Theoretical Biology·L Edelstein-KeshetP Lansdorp
Jul 27, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa J MoranRobert J Norman
Aug 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Brittany Y JarrettMarla E Lujan
Sep 9, 2018·Journal of Mathematical Biology·Alexander LangeSusanna Röblitz
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Lisa J WebberStephen Franks

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