PMID: 1575375Jan 1, 1992

Modelling the dynamic ventilatory response to hypoxia in humans

Annals of Biomedical Engineering
D S WardC B Mann

Abstract

A two-component dynamic model was used to describe the ventilatory response to sustained hypoxia in humans. One component (Xs) represents the stimulating effects of hypoxia and the other component (Xd), the hypoxic ventilatory decline. The total ventilatory response to hypoxia is represented by the sum of the two components. A nonlinearity is included to account for the nonlinear steady-state ventilatory response to hypoxia. A sensitivity analysis of the model indicates that, with a step change in F(ETO2) as the input, all the parameters can be estimated from the data except for the nonlinearity. The relative sensitivity of the parameters from the model analysis was confirmed in an experimental study. However, comparing steps into hypoxia versus steps out of hypoxia we found a decrease in the gains of both components. The most likely explanation for the decrease in the gains is that the combination of Xs and Xd is not entirely additive. Other models may be required to completely describe the ventilatory response to inputs more complex than steps.

References

Jan 1, 1975·Journal of Applied Physiology·A S Rebuck, W E Woodley
Sep 1, 1975·Journal of Applied Physiology·G D Swanson, J W BELLVILLE
Dec 1, 1975·Journal of Applied Physiology·R B Weiskoff, R Gabel
Mar 1, 1990·Journal of Applied Physiology·D S WardC Olievier
Jul 1, 1990·Respiration Physiology·S Khamnei, P A Robbins
Mar 1, 1989·Journal of Applied Physiology·D GeorgopoulosN R Anthonisen
Apr 1, 1989·Journal of Applied Physiology·A SuzukiY Kawakami
Jan 1, 1989·The Journal of Physiology·J F BertholonA Teillac
Dec 1, 1989·Respiration Physiology·C OlievierJ DeGoede
Jan 1, 1987·Respiration Physiology·J J SchuitmakerC Olievier
Sep 1, 1987·Journal of Applied Physiology·M NishimuraY Kawakami
Feb 1, 1988·Journal of Applied Physiology·P A EastonN R Anthonisen
Apr 1, 1988·Journal of Applied Physiology·P A Easton, N R Anthonisen
Dec 1, 1987·British Journal of Haematology·A WallmarkI M Nilsson
Oct 1, 1987·Anesthesiology·J Severinghaus, K H Naifeh
Dec 1, 1972·Journal of Applied Physiology·J V WeilG F Filley
Sep 1, 1972·Respiration Physiology·R KronenbergJ Severinghaus
Aug 1, 1984·Respiration Physiology·J H van BeekC Olievier
Jun 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B J WhippK Wasserman

Related Concepts

Anoxemia
Carbon Dioxide
Dioxygen
Pulmonary Gas Exchange
Respiration
Statistical Sensitivity

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.