Modelling the Economic and Clinical Burden of Non-Alcoholic Steatohepatitis in East Asia: Data from Hong Kong

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Radhika P TampiZobair M Younossi

Abstract

Non-alcoholic steatohepatitis (NASH) is the progressive form of non-alcoholic fatty liver disease (NAFLD) and prevalence is rising in Asia due to increases rates of urbanization, sedentary lifestyles, and poor nutrition. We built a Markov model with 20-year horizon to estimate the burden of NASH in Hong Kong. Cohort size was determined by population size, prevalence of NAFLD, and incidence of NASH in 2017. Health states include hepatic steatosis (NAFL), fibrosis stages 0-3, compensated and decompensated cirrhosis, hepatocellular carcinoma (HCC), post-LT, and liver-related, cardiovascular, and background mortality. Transition probabilities were estimated from literature and we converted 2017 Gazette price from the Hospital Authority of Hong Kong to US dollars. We discounted costs by 3% annually. Health utilities were assumed to be the same as in the US. NASH will cost $1.32 billion and 124 liver transplants over 20 years, with average cost per person-year of $257. Sensitivity analyses show our model is robust in predicting costs for the prevalent population but likely overestimates costs for the incident population. NASH will contribute to a significant clinical and economic burden in Hong Kong over the next two decades. Due to ...Continue Reading

References

Dec 29, 2006·PharmacoEconomics·Rachael L Fleurence, Christopher S Hollenbeak
Nov 3, 2012·Medicine·Zobair M YounossiManirath Srishord
Jun 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·James FungUNKNOWN Hong Kong Liver Health Census Study Group
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Feb 11, 2016·Health and Quality of Life Outcomes·Pegah GolabiZobair M Younossi
Jun 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jonathan Chung-Fai LeungVincent Wai-Sun Wong
Jun 24, 2017·Journal of Hepatology·Jian-Gao FanVincent Wai-Sun Wong
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniArun J Sanyal
Sep 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alina M AllenPatrick S Kamath
Sep 5, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiAndrei Racila

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Citations

Mar 27, 2021·BMC Gastroenterology·Pochamana PhisalprapaNathorn Chaiyakunapruk
Jun 10, 2021·Journal of Gastroenterology and Hepatology·Terry Cheuk-Fung YipGrace Lai-Hung Wong
Jun 25, 2021·Journal of Medical Ultrasonics·Nobuharu TamakiNamiki Izumi
Jun 22, 2021·Journal of Gastroenterology and Hepatology·Nobuharu TamakiNamiki Izumi
Nov 2, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobuharu TamakiNamiki Izumi
Nov 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lina GruneauMartin Henriksson
Sep 9, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nobuharu TamakiRohit Loomba

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