Modelling the effect of mixture components on permeation through skin

International Journal of Pharmaceutics
T GhafourianJim E Riviere

Abstract

A vehicle influences the concentration of penetrant within the membrane, affecting its diffusivity in the skin and rate of transport. Despite the huge amount of effort made for the understanding and modelling of the skin absorption of chemicals, a reliable estimation of the skin penetration potential from formulations remains a challenging objective. In this investigation, quantitative structure-activity relationship (QSAR) was employed to relate the skin permeation of compounds to the chemical properties of the mixture ingredients and the molecular structures of the penetrants. The skin permeability dataset consisted of permeability coefficients of 12 different penetrants each blended in 24 different solvent mixtures measured from finite-dose diffusion cell studies using porcine skin. Stepwise regression analysis resulted in a QSAR employing two penetrant descriptors and one solvent property. The penetrant descriptors were octanol/water partition coefficient, logP and the ninth order path molecular connectivity index, and the solvent property was the difference between boiling and melting points. The negative relationship between skin permeability coefficient and logP was attributed to the fact that most of the drugs in this p...Continue Reading

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Citations

Oct 16, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jim E Riviere, James D Brooks
Feb 22, 2012·Advanced Drug Delivery Reviews·Daniela KaradzovskaJim E Riviere
Jan 15, 2013·International Journal of Pharmaceutics·Daniela KaradzovskaJim E Riviere
Nov 22, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G P MossY Sun
May 10, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qian ZhangMichael S Roberts
Sep 8, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Taravat GhafourianJim E Riviere
Aug 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jason T Chittenden, Jim E Riviere
May 29, 2012·International Journal of Pharmaceutics·Eleftherios G SamarasTaravat Ghafourian
Mar 19, 2015·SAR and QSAR in Environmental Research·P AshrafiY Sun
Jun 25, 2017·Toxicology·Ivanka TsakovskaMark T D Cronin
May 5, 2017·Archives of Toxicology·Aurélie BerthetNancy B Hopf
Oct 3, 2020·Toxicology Letters·Aurelie BerthetNancy B Hopf
Jan 13, 2021·Pharmaceutics·Ekaterina P VasyuchenkoMarine E Bozdaganyan
Jan 19, 2019·Journal of Chemical Information and Modeling·Beatrice PecoraroMatthew Traynor

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