Modelling the impact of antiretroviral use in resource-poor settings

PLoS Medicine
Rebecca F BaggaleyNeil M Ferguson

Abstract

The anticipated scale-up of antiretroviral therapy (ART) in high-prevalence, resource-constrained settings requires operational research to guide policy on the design of treatment programmes. Mathematical models can explore the potential impacts of various treatment strategies, including timing of treatment initiation and provision of laboratory monitoring facilities, to complement evidence from pilot programmes. A deterministic model of HIV transmission incorporating ART and stratifying infection progression into stages was constructed. The impact of ART was evaluated for various scenarios and treatment strategies, with different levels of coverage, patient eligibility, and other parameter values. These strategies included the provision of laboratory facilities that perform CD4 counts and viral load testing, and the timing of the stage of infection at which treatment is initiated. In our analysis, unlimited ART provision initiated at late-stage infection (AIDS) increased prevalence of HIV infection. The effect of additionally treating pre-AIDS patients depended on the behaviour change of treated patients. Different coverage levels for ART do not affect benefits such as life-years gained per person-year of treatment and have mi...Continue Reading

References

Feb 1, 1993·Journal of Clinical Epidemiology·M HeliövaaraO Impivaara
Apr 1, 1996·Annals of Internal Medicine·A S FauciD Weissman
Jun 15, 1997·American Journal of Epidemiology·M A Sanchez, S M Blower
Aug 8, 1998·The New England Journal of Medicine·S H MichaelsP Kissinger
Sep 29, 1999·JAMA : the Journal of the American Medical Association·S J LittleD D Richman
Jan 14, 2000·JAMA : the Journal of the American Medical Association·D V HavlirD D Richman
Mar 14, 2000·JAMA : the Journal of the American Medical Association·J E Gallant
Mar 20, 2001·JAMA : the Journal of the American Medical Association·L M LeeP L Fleming
Aug 15, 2001·Lancet·A D HarriesF M Salaniponi
Aug 2, 2002·The Lancet Infectious Diseases·J X Velasco-HernandezS M Blower
Apr 16, 2003·Annals of Internal Medicine·Frank J PalellaUNKNOWN HIV Outpatient Study Investigators
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gregory M LucasRichard D Moore
Sep 10, 2003·AIDS·Jean-Michel TassieUNKNOWN Médecins Sans Frontières
Sep 10, 2003·AIDS·Nigel Livesley, Chester Morris
Nov 8, 2003·BMJ : British Medical Journal·J S MukherjeeJ Y Kim
Apr 8, 2004·Studies in Family Planning·Norman Hearst, Sanny Chen
Jan 14, 2005·PLoS Medicine·Joshua A SalomonBernhard Schwartländer

❮ Previous
Next ❯

Citations

Dec 7, 2013·The Journal of Infectious Diseases·Sten H Vermund
Mar 9, 2006·PLoS Medicine·Stefano M Bertozzi, Sergio Bautista-Arredondo
Oct 22, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ruthie B BirgerSally L Hodder
Nov 7, 2013·BioMed Research International·Xiaodan SunNing Wang
Oct 17, 2006·PLoS Computational Biology·Andreas HandelRustom Antia
Apr 9, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Susan CasselsMartina Morris
Jul 25, 2008·Sexually Transmitted Infections·L M HeatonP O Way
May 30, 2009·PloS One·Timothy B HallettGeoff P Garnett
Aug 14, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Meghan M ShorterNathan M Thielman
Dec 9, 2010·Sexually Transmitted Infections·Daniel R HoganJoshua A Salomon
Apr 13, 2011·PLoS Computational Biology·Vincent T MetzgerLeor S Weinberger
Apr 21, 2011·Current Opinion in HIV and AIDS·Rebecca F BaggaleyMarie-Claude Boily
Jan 10, 2012·Current Opinion in HIV and AIDS·Myron S CohenTheresa R Gamble
Mar 5, 2013·Current HIV/AIDS Reports·Sten H Vermund, Richard J Hayes
Mar 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neeraj SoodRaffaele Vardavas
Jun 8, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laith J Abu-RaddadIra M Longini
Sep 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Issouf KonateNicolas Nagot
May 25, 2013·The Journal of Infectious Diseases·Valentina CambianoAndrew Phillips
Dec 7, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·V CambianoM J van de Laar
Feb 14, 2009·Bulletin of Mathematical Biology·Wasima Rida, Sonja Sandberg
Jun 15, 2010·Current Opinion in HIV and AIDS·Rebecca F Baggaley, Christophe Fraser
Apr 30, 2013·Médecine sciences : M/S·Virginie Supervie
Apr 7, 2007·AIDS·Frits van Griensven, Seth C Kalichman
Aug 2, 2008·AIDS·Joshua A Salomon, Daniel R Hogan
Mar 14, 2012·AIDS·M Arantxa ColcheroSergio Bautista-Arredondo
Apr 27, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Wendy MurilloIvette Lorenzana de Rivera

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